Protein detail

PRSR2

Proline and serine-rich protein 2

Protein symbol PRSR2	UniProt ID Q86WR7	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Proline and serine-rich protein 2

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000148426

Entrez Gene Symbol

PROSER2

Gene Synonym

C10orf47MGC35403

Gene Description

Proline and serine rich 2

Chromosome

Position

11823339-11872277

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificColonocytesBlood Cell Specificneutrophil

Function & Pathway

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process

Canonical Pathways

M266 Pid ncadherin pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PROSER2	CHEK1	O14757	S	43	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PHF1 PROSER2 RDH13 SLC25A43	O43189 Q86WR7 Q8NBN7 Q8WUT9	0:0:0:0	hu.MAP2
	PROSER2 RDH13 SLC25A43	Q86WR7 Q8NBN7 Q8WUT9	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains

Sequences

Length

435

Mass

45,802

Sequence

MPVTHRKSDASDMNSDTSPSCRLRAFSRGGSLESRSSSSRSRSFTLDDESLKYLTHEEKDVLLFFEETIDSLDEDFEEPVLCDGGVCCLCSPSLEESTSSPSEPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPAGKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPPRRELRAPSPPVEHPRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAARGPRSGDPGPGPSHPAQPKAPRFPSNIIVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLPGPAESLRAGGQAPRGPALANGFPSAHEALKSAPSSFAPAGKSLCFRPGPALPSTRARQSFPGPRQPNGAQDWRRADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRESS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86WR7-1; Sequence=Displayed; Name=2; IsoId=Q86WR7-2; Sequence=VSP_014955

Alternative Sequence

245..338; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

1..10; Basic and acidic residues; 11..20; Polar residues; 92..102; Low complexity; 113..126; Low complexity; 146..169; Pro residues; 228..237; Low complexity; 302..311; Gly residues

Region

1..22; Disordered; 92..276; Disordered; 295..420; Disordered

Clinical Relevance

Antibody

HPA041337