Protein detail

SKAP1

Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)

Entry name SKAP1	UniProt ID Q86WV1	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000141293

Entrez Gene Symbol

SKAP1

Gene Synonym

SCAP1SKAP55

Gene Description

Src kinase associated phosphoprotein 1

Chromosome

Position

48133442-48430275

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04015 Rap1 signaling pathway

Canonical Pathways

M12771 Sa pten pathway
M63 Pid avb3 opn pathway
M275 Pid alpha synuclein pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

9 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SKAP1	FYN	P06241	Y	232	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	KEA:11909961 phosphoELM:11909961
SKAP1	FYN	P06241	Y	219	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPKEAphosphoELM	KEA:11909961 phosphoELM:11909961
SKAP1	FYN	P06241	Y	271	phosphorylation	dbPTM	dbPTM:19690332
SKAP1	FYN	P06241	Y	295	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
SKAP1	FYN	P06241	Y	298	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
SKAP1	PTPRC	P08575	Y	232	dephosphorylation	HPRDSIGNORDEPOD	DEPOD:11909961 HPRD:11909961 SIGNOR:11909961
SKAP1	PTPRC	P08575	Y	232	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11909961
SKAP1	SRC	P12931	Y	219	phosphorylation	Li2012
SKAP1	SRC	P12931	Y	232	phosphorylation	Li2012

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	SKAP1	Q86WV1	Yes	Yes	No	ProtMapperdbPTMHINTphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEABioGRIDphosphoELMPhosphoSiteNetPathSPIKE_LCSPIKE	BioGRID:12171928 SPIKE_LC:12171928 HPRD:9195899 SPIKE:12171928 HINT:10856234 dbPTM:19690332 phosphoELM:11909961 NetPath:12171928 KEA:11909961 HINT:9195899 PhosphoSite:11909961 SPIKE_LC:16713569 HINT:12171928 PhosphoSite:16461356 SPIKE:16713569
PTPRC	P08575	SKAP1	Q86WV1	Yes	Yes	No	SPIKEWangNetPathSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapperLit-BM-17HPRD-phosSPIKE_LC	SPIKE:11909961 HPRD-phos:11909961 NetPath:11909961 DEPOD:11909961 HPRD:11909961 Lit-BM-17:11909961 ProtMapper:11909961 SIGNOR:11909961 SPIKE_LC:11909961

Protein Complex Composition

9 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CC2D1B NPHP4 PAX3 SKAP1 SKAP2 SUGCT	O75161 O75563 P23760 Q5T0F9 Q86WV1 Q9HAC7	0:0:0:0:0:0	hu.MAP
NPHP4 PAX3 SKAP1 SKAP2	O75161 O75563 P23760 Q86WV1	0:0:0:0	hu.MAP
CC2D1B PAX3 SKAP1 SKAP2	O75563 P23760 Q5T0F9 Q86WV1	0:0:0:0	hu.MAP
CC2D1B PAX3 SKAP1 SKAP2 SUGCT	O75563 P23760 Q5T0F9 Q86WV1 Q9HAC7	0:0:0:0:0	hu.MAP2
PAX3 PKN3 SKAP1 SKAP2 SUGCT	O75563 P23760 Q6P5Z2 Q86WV1 Q9HAC7	0:0:0:0:0	hu.MAP2
PAX3 SKAP1 SKAP2	O75563 P23760 Q86WV1	0:0:0	hu.MAP2
PAX3 SKAP1 SKAP2 SUGCT	O75563 P23760 Q86WV1 Q9HAC7	0:0:0:0	hu.MAP
PAX3 SKAP1	P23760 Q86WV1	0:0	hu.MAP2
SKAP1	Q86WV1	4	PDB	PDB:1u5d

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	33204424

Sequence, Structure & Domains

Sequences

Length

359

Mass

41,432

Sequence

MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPKEYLTTAFEVEER

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86WV1-1; Sequence=Displayed; Name=2; IsoId=Q86WV1-2; Sequence=VSP_022179

Alternative Sequence

293; Missing (in isoform 2)

3D Structural Models

Helix

166..168; 172..176; 195..212

Beta Strand

108..119; 121..124; 126..136; 139..145; 152..156; 161..164; 177..181; 183..185; 188..191

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

219..237; Acidic residues

Domain (CC)

The SH3 domain interacts with FYB1.

Domain (FT)

107..210; PH; 294..355; SH3

Region

219..239; Disordered; 290..295; Interaction with FYB1

Protein Families

SKAP family

Sequence Similarities

Belongs to the SKAP family.

Clinical Relevance

Antibody

HPA002969 CAB025882 CAB055513

Interaction Protein

ENSG00000082074

Interaction Count

Interaction Dataset

intact_biogrid