Protein detail

DGKH

Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)

Entry name
DGKH
UniProt ID
Q86XP1
EVMP confidence score
0.50
Supporting publications (n)
5
Transmembrane count
Protein classification
EnzymesMetabolic proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Ensembl
ENSG00000102780
Entrez Gene Symbol
DGKH
Gene Synonym
DGKeta
Gene Description
Diacylglycerol kinase eta
Chromosome
13
Position
42040036-42256578
Supporting publications (n)
5
EVMP confidence score
0.50
Fluorescence & Localization1
DGKH fluorescence
Function & Pathway8
Protein Function (3)
  • ENZYME proteins:Transferases
  • Enzymes
  • Predicted intracellular proteins
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
KEGG (6)
Reactome (5)
Canonical Pathways (2)
  • M257 Pid ephrinb rev pathway
  • M7 Pid fcer1 pathway
Mediation Categories (3)
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence14

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo

Protein Complex Composition (6)

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry24018949741307968
Sequence, Structure & Domains13

Sequences

Length
1,220
Mass
134,866
Sequence
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=DAG kinase eta-2, DGKH-2; IsoId=Q86XP1-1; Sequence=Displayed; Name=2; Synonyms=DAG kinase eta-1, DGKH-1; IsoId=Q86XP1-2; Sequence=VSP_019185; Name=3; IsoId=Q86XP1-3; Sequence=VSP_019183, VSP_019186; Name=4; IsoId=Q86XP1-5; Sequence=VSP_019183
Alternative Sequence
1..136; Missing (in isoform 3 and isoform 4); 1148..1220; VQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV -> GSGDTESGSCEANSPGN (in isoform 2); 1191; K -> KNTVGEKRDTKENGKHM (in isoform 3)

Domain & Motif Annotations

Compositional Bias
20..35; Low complexity; 581..592; Acidic residues; 593..604; Basic and acidic residues
Motif
1218..1220; PDZ-binding
Zinc Finger
175..225; Phorbol-ester/DAG-type 1; 247..298; Phorbol-ester/DAG-type 2
Domain (CC)
The SAM domain mediates homooligomerization.
Domain (FT)
65..158; PH; 328..463; DAGKc; 1151..1214; SAM
Region
1..60; Disordered; 581..617; Disordered; 636..705; Disordered
Protein Families
Eukaryotic diacylglycerol kinase family
Sequence Similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Clinical Relevance1
Antibody (3)
HPA039533HPA040355HPA061538
Supporting Publications5
PMIDTitleAbstract
24505114Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
26801919Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.No abstract available
31588238Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.No abstract available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No abstract available
40098346Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.No abstract available