Protein detail
DGKH
Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Entry name DGKH | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 5 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DGKeta
Gene Description
Diacylglycerol kinase eta
Chromosome
13
Position
42040036-42256578
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Function & Pathway
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
KEGG (6)
Reactome (5)
Canonical Pathways (2)
- M257 Pid ephrinb rev pathway
- M7 Pid fcer1 pathway
Mediation Categories (3)
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence14
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DEUP1DGKHHIP1MAFG | O00291O15525Q05D60Q86XP1 | 0:0:0:0 | hu.MAP | |||
| DEUP1DGKHGOLGA3HIP1TRAF6 | O00291Q05D60Q08378Q86XP1Q9Y4K3 | 0:0:0:0:0 | hu.MAP | |||
| DEUP1DGKH | Q05D60Q86XP1 | 0:0 | hu.MAP | |||
| DEUP1DGKHSPAG5 | Q05D60Q86XP1Q96R06 | 0:0:0 | hu.MAP2 | |||
| DGKHEIF1ADHBS1LMAGIXPPIL4TJP1 | Q07157Q86XP1Q8N9N8Q8WUA2Q9H6Y5Q9Y450 | 0:0:0:0:0:0 | hu.MAP2 | |||
| DGKH | Q86XP1 | 0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
1,220
Mass
134,866
Sequence
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=DAG kinase eta-2, DGKH-2; IsoId=Q86XP1-1; Sequence=Displayed; Name=2; Synonyms=DAG kinase eta-1, DGKH-1; IsoId=Q86XP1-2; Sequence=VSP_019185; Name=3; IsoId=Q86XP1-3; Sequence=VSP_019183, VSP_019186; Name=4; IsoId=Q86XP1-5; Sequence=VSP_019183
Alternative Sequence
1..136; Missing (in isoform 3 and isoform 4); 1148..1220; VQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV -> GSGDTESGSCEANSPGN (in isoform 2); 1191; K -> KNTVGEKRDTKENGKHM (in isoform 3)
Domain & Motif Annotations
Compositional Bias
20..35; Low complexity; 581..592; Acidic residues; 593..604; Basic and acidic residues
Motif
1218..1220; PDZ-binding
Zinc Finger
175..225; Phorbol-ester/DAG-type 1; 247..298; Phorbol-ester/DAG-type 2
Domain (CC)
The SAM domain mediates homooligomerization.
Domain (FT)
65..158; PH; 328..463; DAGKc; 1151..1214; SAM
Region
1..60; Disordered; 581..617; Disordered; 636..705; Disordered
Protein Families
Eukaryotic diacylglycerol kinase family
Sequence Similarities
Belongs to the eukaryotic diacylglycerol kinase family.
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 24505114 | Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. | These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4. |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No related sentences available |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |