Protein detail
DGKH
Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Protein symbol DGKH | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DGKeta
Gene Description
Diacylglycerol kinase eta
Chromosome
13
Position
42040036-42256578
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M257 Pid ephrinb rev pathway
- M7 Pid fcer1 pathway
Mediation Categories
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DEUP1DGKHHIP1MAFG | O00291O15525Q05D60Q86XP1 | 0:0:0:0 | hu.MAP | |||
| DEUP1DGKHGOLGA3HIP1TRAF6 | O00291Q05D60Q08378Q86XP1Q9Y4K3 | 0:0:0:0:0 | hu.MAP | |||
| DEUP1DGKH | Q05D60Q86XP1 | 0:0 | hu.MAP | |||
| DEUP1DGKHSPAG5 | Q05D60Q86XP1Q96R06 | 0:0:0 | hu.MAP2 | |||
| DGKHEIF1ADHBS1LMAGIXPPIL4TJP1 | Q07157Q86XP1Q8N9N8Q8WUA2Q9H6Y5Q9Y450 | 0:0:0:0:0:0 | hu.MAP2 | |||
| DGKH | Q86XP1 | 0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
1,220
Mass
134,866
Sequence
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQIRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQELAHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=DAG kinase eta-2, DGKH-2; IsoId=Q86XP1-1; Sequence=Displayed; Name=2; Synonyms=DAG kinase eta-1, DGKH-1; IsoId=Q86XP1-2; Sequence=VSP_019185; Name=3; IsoId=Q86XP1-3; Sequence=VSP_019183, VSP_019186; Name=4; IsoId=Q86XP1-5; Sequence=VSP_019183
Alternative Sequence
1..136; Missing (in isoform 3 and isoform 4); 1148..1220; VQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSEV -> GSGDTESGSCEANSPGN (in isoform 2); 1191; K -> KNTVGEKRDTKENGKHM (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
20..35; Low complexity; 581..592; Acidic residues; 593..604; Basic and acidic residues
Motif
1218..1220; PDZ-binding
Zinc Finger
175..225; Phorbol-ester/DAG-type 1; 247..298; Phorbol-ester/DAG-type 2
Domain (CC)
The SAM domain mediates homooligomerization.
Domain (FT)
65..158; PH; 328..463; DAGKc; 1151..1214; SAM
Region
1..60; Disordered; 581..617; Disordered; 636..705; Disordered
Protein Families
Eukaryotic diacylglycerol kinase family
Sequence Similarities
Belongs to the eukaryotic diacylglycerol kinase family.