Protein detail

AN13B

Ankyrin repeat domain-containing protein 13B

Protein symbol AN13B	UniProt ID Q86YJ7	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Ankyrin repeat domain-containing protein 13B

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000198720

Entrez Gene Symbol

ANKRD13B

Gene Synonym

FLJ25555

Gene Description

Ankyrin repeat domain 13B

Chromosome

Position

29589769-29614761

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissue

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0140036 ubiquitin-modified protein reader activity

Biological Process

Canonical Pathways

M277 Pid integrin a4b1 pathway
M16 Pid insulin pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ANKRD13B GNAI3 GNAT2 RAP1GAP	P08754 P19087 P47736 Q86YJ7	0:0:0:0	hu.MAP
	ANKRD13B GNAI3 RAP1GAP	P08754 P47736 Q86YJ7	0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]	36	23161513 37205098 34817906 32795414 23161513 38014595 30915084 36982312 35611462 32944193 36612172 30379855 30585730 37786918 38168906 40748658 39505756 34817906 28986585 40563475 22740476 27894104 29045505 30646616 31941606 32295833 34571828 38321535 40089067 32089743 39940641 19837982 37438638 19837982 40563475 34980157

Sequence, Structure & Domains

Sequences

Length

626

Mass

70,205

Sequence

MIPANASARKGPEGKYPLHYLVWHNRHRELEKEVRAGQVDIEQLDPRGRTPLHLATTLGHLECARVLLAHGADVGRENRSGWTVLQEAVSTRDLELVQLVLRYRDYQRVVKRLAGIPVLLEKLRKAQDFYVEMKWEFTSWVPLVSKICPSDTYKVWKSGQNLRVDTTLLGFDHMTWQRGNRSFVFRGQDTSAVVMEIDHDRRVVYTETLALAGQDRELLLAAAQPTEEQVLSRLTAPVVTTQLDTKNISFERNKTGILGWRSEKTEMVNGYEAKVYGASNVELITRTRTEHLSEQHKGKVKGCKTPLQSFLGIAEQHGGPQNGTLITQTLSQANPTAITAEEYFNPNFELGNRDMGRPMELTTKTQKFKAKLWLCEEHPLSLCEQVAPIIDLMAVSNALFAKLRDFITLRLPPGFPVKIEIPIFHILNARITFGNLNGCDEPVPSVRGSPSSETPSPGSDSSSVSSSSSTTSCRGCEISPALFEAPRGYSMMGGQREAATRDDDDDLLQFAIQQSLLEAGSEYDQVTIWEALTNSKPGTHPMSYEGRRQDRSAPPTPQRQPAPPASVPSPRPSSGPGSGGHVFRSYDEQLRLAMELSAQEQEERRRRARQEEEELERILRLSLTEQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86YJ7-1; Sequence=Displayed; Name=2; IsoId=Q86YJ7-2; Sequence=VSP_019404

Alternative Sequence

1..132; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

449..472; Low complexity; 554..573; Pro residues

Repeat

47..76; ANK 1; 80..109; ANK 2

Domain (FT)

503..522; UIM 1; 585..604; UIM 2; 610..626; UIM 3

Region

442..474; Disordered; 534..590; Disordered; 595..614; Disordered

Clinical Relevance

Antibody

HPA051886 HPA063748