Protein detail

PDPN

Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]

Entry name PDPN	UniProt ID Q86YL7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

132..152; Helical

Transmembrane Count

Ensembl

ENSG00000162493

Entrez Gene Symbol

PDPN

Gene Synonym (6)

aggrusD2-40Gp38GP40PA2.26T1A-2

Gene Description

Podoplanin

Chromosome

Position

13583465-13617957

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificesophagusCell SpecificEsophageal apical cellsBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component (20)

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Molecular Function (4)

Biological Process (3)

Reactome (5)

Canonical Pathways (3)

M33 Pid glypican 1pathway
M165 Pid syndecan 4 pathway
M266 Pid ncadherin pathway

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence31

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PDPN	Q86YL7	2	PDB	PDB:4yo0PDB:7c94PDB:5xcv
	CLEC1B PDPN	Q86YL7 Q9P126	2:2	PDB	PDB:3wsr

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods	Mass spectrometry	27	36406491 37862381 39949490 26538482 31508500 38225453 39873726 40545963 38644352 32795414 38731868 2353145 25471207 26801919 27723984 28242843 30353492 33580265 33709510 22106071 37686366 38490958 41201090 30760538 37922300 39835386 36332889

Sequence, Structure & Domains11

Sequences

Length

162

Mass

16,698

Sequence

MWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGFIGAIIVVVMRKMSGRYSP

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=hT1alpha-2; IsoId=Q86YL7-1; Sequence=Displayed; Name=2; Synonyms=hT1alpha-1; IsoId=Q86YL7-2; Sequence=VSP_051949, VSP_051950, VSP_051951; Name=3; IsoId=Q86YL7-3; Sequence=VSP_035753; Name=4; IsoId=Q86YL7-4; Sequence=VSP_035753, VSP_035754; Name=5; IsoId=Q86YL7-5; Sequence=VSP_046799, VSP_046800; Name=6; IsoId=Q86YL7-6; Sequence=VSP_046799

Alternative Sequence

1..100; Missing (in isoform 2); 1..42; Missing (in isoform 5 and isoform 6); 1; M -> MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRSSRLGLWPRCFLIFPQLRILLLGPQESNNSTGTM (in isoform 3 and isoform 4); 101..123; ASNVATSHSTEKVDGDTQTTVEK -> MLHILSPMYFFLWGSCFFPLSSS (in isoform 2); 160..162; YSP -> P (in isoform 4); 160..161; Missing (in isoform 5); 162; P -> EVNSLHPCDRQMKAIVSRTQIFELIEISDISWVWWLVPVVSAAGQLQTSLGNIVRPCLKKIISGTMVMFQSSLLGPLECSGSHLESQCFERLRRQEVHLCPGI (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

85..108; Polar residues; 109..119; Basic and acidic residues

Domain (CC)

The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (PubMed:25486435).

Region

23..57; Disordered; 85..119; Disordered; 133..137; Requires for dimerization and lipid rafts association; 154..155; Requires for interaction with MSN and EZR

Protein Families

Podoplanin family

Sequence Similarities

Belongs to the podoplanin family.

Clinical Relevance1

Antibody (3)

HPA007534 HPA007949 CAB008376

Supporting Publications1

PMID	Title	Abstract
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available