Protein detail
PDPN
Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Protein symbol PDPN | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
132..152; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
aggrusD2-40Gp38GP40PA2.26T1A-2
Gene Description
Podoplanin
Chromosome
1
Position
13583465-13617957
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0001726 ruffle
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
- GO:0030054 cell junction
- GO:0030175 filopodium
- GO:0031258 lamellipodium membrane
- GO:0031410 cytoplasmic vesicle
- GO:0031527 filopodium membrane
- GO:0031528 microvillus membrane
- GO:0032587 ruffle membrane
- GO:0042995 cell projection
- GO:0045121 membrane raft
- GO:0061851 leading edge of lamellipodium
- GO:0070161 anchoring junction
- GO:0097197 tetraspanin-enriched microdomain
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M33 Pid glypican 1pathway
- M165 Pid syndecan 4 pathway
- M266 Pid ncadherin pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods | Mass spectrometry | 27 | 36406491378623813994949026538482315085003822545339873726405459633864435232795414387318682353145254712072680191927723984282428433035349233580265337095102210607137686366384909584120109030760538379223003983538636332889 |
Sequence, Structure & Domains
Sequences
Length
162
Mass
16,698
Sequence
MWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGFIGAIIVVVMRKMSGRYSP
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=hT1alpha-2; IsoId=Q86YL7-1; Sequence=Displayed; Name=2; Synonyms=hT1alpha-1; IsoId=Q86YL7-2; Sequence=VSP_051949, VSP_051950, VSP_051951; Name=3; IsoId=Q86YL7-3; Sequence=VSP_035753; Name=4; IsoId=Q86YL7-4; Sequence=VSP_035753, VSP_035754; Name=5; IsoId=Q86YL7-5; Sequence=VSP_046799, VSP_046800; Name=6; IsoId=Q86YL7-6; Sequence=VSP_046799
Alternative Sequence
1..100; Missing (in isoform 2); 1..42; Missing (in isoform 5 and isoform 6); 1; M -> MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRSSRLGLWPRCFLIFPQLRILLLGPQESNNSTGTM (in isoform 3 and isoform 4); 101..123; ASNVATSHSTEKVDGDTQTTVEK -> MLHILSPMYFFLWGSCFFPLSSS (in isoform 2); 160..162; YSP -> P (in isoform 4); 160..161; Missing (in isoform 5); 162; P -> EVNSLHPCDRQMKAIVSRTQIFELIEISDISWVWWLVPVVSAAGQLQTSLGNIVRPCLKKIISGTMVMFQSSLLGPLECSGSHLESQCFERLRRQEVHLCPGI (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
85..108; Polar residues; 109..119; Basic and acidic residues
Domain (CC)
The cytoplasmic domain controls FRC elongation but is dispensable for contraction (By similarity). The cytoplasmic domain is essential for recruitment to invadopodia and ECM degradation (PubMed:25486435).
Region
23..57; Disordered; 85..119; Disordered; 133..137; Requires for dimerization and lipid rafts association; 154..155; Requires for interaction with MSN and EZR
Protein Families
Podoplanin family
Sequence Similarities
Belongs to the podoplanin family.