Protein detail
S13A5
Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)
Protein symbol S13A5 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 11 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
15..28; Helical; Name=1; 34..49; Helical; Name=2; 56..69; Helical; Name=3; 75..117; Discontinuously helical; Name=4; 203..240; Discontinuously helical; Name=5; 250..276; Helical; Name=6; 315..332; Helical; Name=7; 356..368; Helical; Name=8; 399..435; Discontinuously helical; Name=9; 487..517; Discontinuously helical; Name=10; 523..551; Helical; Name=11
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
INDYNACT
Gene Description
Solute carrier family 13 member 5
Chromosome
17
Position
6684719-6713377
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M1315 Sig pip3 signaling in b lymphocytes
- M8626 Sig bcr signaling pathway
- M88 Pid cd8 tcr pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
568
Mass
63,062
Sequence
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHIET
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86YT5-1; Sequence=Displayed; Name=2; IsoId=Q86YT5-2; Sequence=VSP_043098; Name=3; IsoId=Q86YT5-3; Sequence=VSP_054910; Name=4; IsoId=Q86YT5-4; Sequence=VSP_055652
Alternative Sequence
35..77; Missing (in isoform 4); 124..140; Missing (in isoform 3); 479..524; Missing (in isoform 2)
3D Structural Models
Turn
224..226; 460..462; 553..555
Helix
14..19; 22..24; 25..28; 34..51; 56..69; 75..79; 80..82; 85..102; 105..117; 121..136; 141..157; 202..220; 228..240; 250..275; 292..309; 314..333; 356..367; 399..405; 408..426; 429..437; 438..441; 445..459; 465..482; 487..498; 505..507; 509..516; 522..545; 547..552; 559..561
Beta Strand
246..248; 370..373
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Motif
140..142; SNT motif; 227..229; TXP motif
Domain (CC)
The SNT motif and TXP motif are essential for substrate recognition.
Protein Families
- SLC13A/DASS transporter (TC 2.A.47) family
- NADC subfamily
Sequence Similarities
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Clinical Relevance
Disease Involvement
Amelogenesis imperfectaDisease variantEpilepsy
Antibody