Protein detail

S13A5

Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)

Entry name S13A5	UniProt ID Q86YT5	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 11	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5)

Protein Class (6)

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Transporters:Electrochemical Potential-driven transporters
Potential drug targets

Transmembrane

15..28; Helical; Name=1; 34..49; Helical; Name=2; 56..69; Helical; Name=3; 75..117; Discontinuously helical; Name=4; 203..240; Discontinuously helical; Name=5; 250..276; Helical; Name=6; 315..332; Helical; Name=7; 356..368; Helical; Name=8; 399..435; Discontinuously helical; Name=9; 487..517; Discontinuously helical; Name=10; 523..551; Helical; Name=11

Transmembrane Count

Ensembl

ENSG00000141485

Entrez Gene Symbol

SLC13A5

Gene Synonym (2)

INDYNACT

Gene Description

Solute carrier family 13 member 5

Chromosome

Position

6684719-6713377

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificColonocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway7

Protein Function (4)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Transporters:Electrochemical Potential-driven transporters
Potential drug targets

Cellular Component (3)

Molecular Function (6)

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M1315 Sig pip3 signaling in b lymphocytes
M8626 Sig bcr signaling pathway
M88 Pid cd8 tcr pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence21

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC13A5	Q86YT5	2	PDB	PDB:8uvhPDB:7jsjPDB:7jskPDB:8uvb

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	24393738 33709510 39478498

Sequence, Structure & Domains13

Sequences

Length

568

Mass

63,062

Sequence

MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHIET

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86YT5-1; Sequence=Displayed; Name=2; IsoId=Q86YT5-2; Sequence=VSP_043098; Name=3; IsoId=Q86YT5-3; Sequence=VSP_054910; Name=4; IsoId=Q86YT5-4; Sequence=VSP_055652

Alternative Sequence

35..77; Missing (in isoform 4); 124..140; Missing (in isoform 3); 479..524; Missing (in isoform 2)

3D Structural Models

Turn

224..226; 460..462; 553..555

Helix

14..19; 22..24; 25..28; 34..51; 56..69; 75..79; 80..82; 85..102; 105..117; 121..136; 141..157; 202..220; 228..240; 250..275; 292..309; 314..333; 356..367; 399..405; 408..426; 429..437; 438..441; 445..459; 465..482; 487..498; 505..507; 509..516; 522..545; 547..552; 559..561

Beta Strand

246..248; 370..373

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Motif

140..142; SNT motif; 227..229; TXP motif

Domain (CC)

The SNT motif and TXP motif are essential for substrate recognition.

Protein Families (2)

SLC13A/DASS transporter (TC 2.A.47) family
NADC subfamily

Sequence Similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

Clinical Relevance3

Disease Involvement (3)

Amelogenesis imperfectaDisease variantEpilepsy

Drugs (5)

ETG-5773 COMPOUND 7 [PMID: 37428122]PF-06761281 BI01383298 PF-06649298

Antibody

HPA044343

Supporting Publications2

PMID	Title	Abstract
28242843	Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available