Protein detail
RASL3
RAS protein activator like-3
Entry name RASL3 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 5 | Transmembrane count | Protein classification Predicted intracellular proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
RAS protein activator like-3
Protein Class (2)
Predicted intracellular proteinsRAS pathway related proteins
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ21438
Gene Description
RAS protein activator like 3
Chromosome
19
Position
15451624-15464544
Supporting publications (n)
5
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificNK-cellBlood Lineage Specificdendritic cellsSecretome LocationSecreted in other tissuesSecretome FunctionTransport
Function & Pathway
Protein Function (2)
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Sequence, Structure & Domains
Sequences
Length
1,011
Mass
111,898
Sequence
MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86YV0-1; Sequence=Displayed; Name=2; IsoId=Q86YV0-2; Sequence=VSP_033824
Alternative Sequence
944..1011; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
7..22; Low complexity; 81..95; Basic residues; 100..117; Acidic residues; 118..131; Pro residues; 179..190; Basic and acidic residues; 792..808; Basic and acidic residues; 871..882; Polar residues; 987..999; Polar residues
Coiled Coil
888..988
Domain (FT)
197..293; PH; 284..404; C2; 474..682; Ras-GAP
Region
1..38; Disordered; 52..136; Disordered; 151..197; Disordered; 209..230; Disordered; 756..885; Disordered; 987..1011; Disordered
Clinical Relevance
Antibody
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |