Protein detail

RB6I2

ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)

Entry name RB6I2	UniProt ID Q8IUD2	EVMP confidence score 0.72
Supporting publications (n) 20	Transmembrane count	Protein classification Cancer-related genesDisease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)

Protein Class (3)

Cancer-related genesDisease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Ensembl

ENSG00000082805

Entrez Gene Symbol

ERC1

Gene Synonym (5)

CAST2ELKSKIAA1081MGC12974RAB6IP2

Gene Description

ELKS/RAB6-interacting/CAST family member 1

Chromosome

Position

990509-1495933

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization5

Tissue SpecificovaryCell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Cellular Component (10)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Canonical Pathways (3)

M237 Pid vegfr1 2 pathway
M48 Pid met pathway
M186 Pid pdgfrb pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence25

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RB6I2	Q8IUD2	IKKA	O15111	Yes	Yes	No	WangMacrophageSIGNOR	Macrophage:17072322 SIGNOR:15218148 Macrophage:16970925 Macrophage:15218526 Macrophage:16497931 Macrophage:15371334
RB6I2	Q8IUD2		COMPLEX:O14920_O15111_Q9Y6K9	Yes	Yes	No	SIGNOR	SIGNOR:15218148

Protein Complex Composition (17)

17 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CHUK-ERC1-IKBKB-IKBKG	CHUK ERC1 IKBKB IKBKG	O14920 O15111 Q8IUD2 Q9Y6K9	1:1:1:1	CompleatCORUM	Compleat:HC3247CORUM:2118	15218148
TSC2-HERC1 complex	HERC1 TSC2	P49815 Q15751	0:0	CORUM	CORUM:6532	16464865
Ub:HECT_E3	HERC1 UBB	P0CG47 Q15751	0:0	SIGNOR	SIGNOR:SIGNOR-C518
Ub:HECT_E3	HERC1 UBC	P0CG48 Q15751	0:0	SIGNOR	SIGNOR:SIGNOR-C518
Ub:HECT_E3	HERC1 RPS27A	P62979 Q15751	0:0	SIGNOR	SIGNOR:SIGNOR-C518
Ub:HECT_E3	HERC1 UBA52	P62987 Q15751	0:0	SIGNOR	SIGNOR:SIGNOR-C518
p532-Clathrin-HSP70 complex	CLTC HERC1 HSPA1A	P0DMV8 Q00610 Q15751	0:0:0	CORUM	CORUM:7269	9233772
	CARD8 EPDR1 ERC1 LRIF1 PRR20C SMCHD1 TSHB	A6NHR9 P01222 P86479 Q5T3J3 Q8IUD2 Q9UM22 Q9Y2G2	0:0:0:0:0:0:0	hu.MAP2
	CBY2 ERC1 LRIF1 SMCHD1 TSHB	A6NHR9 P01222 Q5T3J3 Q8IUD2 Q8NA61	0:0:0:0:0	hu.MAP2
	ATP6V0D1 ERC1 ERC2 NCBP1 NCBP2	O15083 P52298 P61421 Q09161 Q8IUD2	0:0:0:0:0	Havugimana2012	Havugimana2012:C_457

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	33204424 39766158 39940923 27894104

Sequence, Structure & Domains9

Sequences

Length

1,116

Mass

128,086

Sequence

MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=ELKS epsilon; IsoId=Q8IUD2-1; Sequence=Displayed; Name=2; Synonyms=ELKS beta; IsoId=Q8IUD2-2; Sequence=VSP_011451, VSP_011452, VSP_011454, VSP_011455; Name=3; Synonyms=ELKS delta; IsoId=Q8IUD2-3; Sequence=VSP_011451; Name=4; Synonyms=ELKS alpha; IsoId=Q8IUD2-4; Sequence=VSP_011451, VSP_011452, VSP_011453, VSP_011454, VSP_011455; Name=5; Synonyms=ELKS gamma; IsoId=Q8IUD2-5; Sequence=VSP_011450, VSP_011452, VSP_011454, VSP_011455

Alternative Sequence

224..523; Missing (in isoform 5); 440..467; Missing (in isoform 2, isoform 3 and isoform 4); 783; E -> ESLTS (in isoform 2, isoform 4 and isoform 5); 830..873; Missing (in isoform 4); 1009..1016; IIQPLLEL -> DEEEGIWA (in isoform 2, isoform 4 and isoform 5); 1017..1116; Missing (in isoform 2, isoform 4 and isoform 5)

Domain & Motif Annotations

Compositional Bias

13..28; Low complexity; 40..51; Gly residues; 590..602; Basic and acidic residues

Coiled Coil

144..988; 1060..1100

Domain (FT)

1046..1108; FIP-RBD

Region

1..54; Disordered; 590..609; Disordered; 814..836; Disordered

Clinical Relevance5

Disease Involvement

Cancer-related genes

Antibody (3)

HPA019513 HPA019523 HPA024130

Interaction Protein (2)

ENSG00000046651ENSG00000170027

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications20

PMID	Title	Abstract
36635400	Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
37702715	One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles.	No abstract available
38082559	Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia.	No abstract available
38164498	Enrichment of sweat-derived extracellular vesicles of human and bacterial origin for biomarker identification.	No abstract available
38612515	Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature.	No abstract available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available
39835386	Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available

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