Protein detail

ZNG1B

Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)

Entry name
ZNG1B
UniProt ID
Q8IUF1
EVMP confidence score
0.28
Supporting publications (n)
1
Transmembrane count
Protein classification
Essential proteinsPredicted intracellular proteins
Basic Information
Protein Names
Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)
Protein Class (2)
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000136682
Entrez Gene Symbol
ZNG1B
Gene Synonym
CBWD2
Gene Description
Zn regulated GTPase metalloprotein activator 1B
Chromosome
2
Position
113437691-113496204
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificNeutrophilsSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Canonical Pathways
M60 Pid nfat tfpathway
Mediation Categories
Other mediation
Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]139408670
Sequence, Structure & Domains

Sequences

Length
395
Mass
44,034
Sequence
MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLAEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRATIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Domain & Motif Annotations

Compositional Bias
8..20; Acidic residues
Motif
17..24; psi-PxLVp motif; 107..110; CXCC motif
Domain (FT)
274..377; CobW C-terminal
Region
1..36; Disordered
Protein Families (2)
  • SIMIBI class G3E GTPase family
  • ZNG1 subfamily
Sequence Similarities
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Clinical Relevance
Antibody (2)
HPA042759HPA042813
Supporting Publications1
PMIDTitleRelated sentences
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No related sentences available