Protein detail
ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)
Entry name ZNG1B | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Essential proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Zinc-regulated GTPase metalloprotein activator 1B (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 2) (COBW domain-containing protein 2)
Protein Class (2)
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CBWD2
Gene Description
Zn regulated GTPase metalloprotein activator 1B
Chromosome
2
Position
113437691-113496204
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecifickidneyCell SpecificNeutrophilsSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Canonical Pathways
M60 Pid nfat tfpathway
Mediation Categories
Other mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF] | 1 | 39408670 |
Sequence, Structure & Domains9
Sequences
Length
395
Mass
44,034
Sequence
MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLAEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRATIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT
Domain & Motif Annotations
Compositional Bias
8..20; Acidic residues
Motif
17..24; psi-PxLVp motif; 107..110; CXCC motif
Domain (FT)
274..377; CobW C-terminal
Region
1..36; Disordered
Protein Families (2)
- SIMIBI class G3E GTPase family
- ZNG1 subfamily
Sequence Similarities
Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |