Protein detail
CRLF3
Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)
Entry name CRLF3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CREME9CYTOR4
Gene Description
Cytokine receptor like factor 3
Chromosome
17
Position
30769388-30824692
Supporting publications (n)
4
EVMP confidence score
0.38
Fluorescence & Localization5
Cell SpecificNeutrophilsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Canonical Pathways
M72 Pid nectin pathway
Mediation Categories
Other mediation
Relations & Evidence18
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| secreted | secreted | Matrisome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | No | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
| ligand | ligand | Matrisome | Yes | No | Yes | No | No |
Page 1 of 2Next
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AGTRAPCRLF3ENPP6MEX3B | Q6RW13Q6UWR7Q6ZN04Q8IUI8 | 0:0:0:0 | hu.MAP | |||
| CRLF3ENPP6MEX3BSACS | Q6UWR7Q6ZN04Q8IUI8Q9NZJ4 | 0:0:0:0 | hu.MAP | |||
| CRLF3ENPP6 | Q6UWR7Q8IUI8 | 0:0 | hu.MAP2 | |||
| CRLF3FAM200C | Q8IUI8Q8IZ13 | 0:0 | hu.MAP2 | |||
| CRLF3FAM200CZNF507 | Q8IUI8Q8IZ13Q8TCN5 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains9
Sequences
Length
442
Mass
49,766
Sequence
MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p48.6; IsoId=Q8IUI8-1; Sequence=Displayed; Name=2; Synonyms=p48.2; IsoId=Q8IUI8-2; Sequence=VSP_044648
Alternative Sequence
1..4; Missing (in isoform 2)
Domain & Motif Annotations
Coiled Coil
10..57
Domain (FT)
181..274; Fibronectin type-III
Protein Families
Cytokine receptor-like factor 3 family
Sequence Similarities
Belongs to the cytokine receptor-like factor 3 family.
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000131475
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |