Protein detail

CRLF3

Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)

Entry name CRLF3	UniProt ID Q8IUI8	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000176390

Entrez Gene Symbol

CRLF3

Gene Synonym

CREME9CYTOR4

Gene Description

Cytokine receptor like factor 3

Chromosome

Position

30769388-30824692

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificNeutrophilsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M72 Pid nectin pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted	secreted	Matrisome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	No	No
cell_surface	cell_surface	OmniPath	No	No	Yes	No	No
ligand	ligand	Matrisome	Yes	No	Yes	No	No

Page 1 of 2Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
AGTRAP CRLF3 ENPP6 MEX3B	Q6RW13 Q6UWR7 Q6ZN04 Q8IUI8	0:0:0:0	hu.MAP
CRLF3 ENPP6 MEX3B SACS	Q6UWR7 Q6ZN04 Q8IUI8 Q9NZJ4	0:0:0:0	hu.MAP
CRLF3 ENPP6	Q6UWR7 Q8IUI8	0:0	hu.MAP2
CRLF3 FAM200C	Q8IUI8 Q8IZ13	0:0	hu.MAP2
CRLF3 FAM200C ZNF507	Q8IUI8 Q8IZ13 Q8TCN5	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFlow cytometry	4	33204424 40748658 30950185 20031610

Sequence, Structure & Domains

Sequences

Length

442

Mass

49,766

Sequence

MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=p48.6; IsoId=Q8IUI8-1; Sequence=Displayed; Name=2; Synonyms=p48.2; IsoId=Q8IUI8-2; Sequence=VSP_044648

Alternative Sequence

1..4; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Coiled Coil

10..57

Domain (FT)

181..274; Fibronectin type-III

Protein Families

Cytokine receptor-like factor 3 family

Sequence Similarities

Belongs to the cytokine receptor-like factor 3 family.

Clinical Relevance

Antibody

HPA007596

Interaction Protein

ENSG00000131475

Interaction Count

Interaction Dataset

intact_biogrid