Protein detail

RELL1

RELT-like protein 1

Entry name RELL1	UniProt ID Q8IUW5	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

RELT-like protein 1

Protein Class

Predicted membrane proteins

Transmembrane

58..78; Helical

Transmembrane Count

Ensembl

ENSG00000181826

Entrez Gene Symbol

RELL1

Gene Description

RELT like 1

Chromosome

Position

37590800-37686376

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway5

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Mediation Categories

Receptor-signaling mediation

Relations & Evidence34

Ligand-Receptor Signaling (30)

30 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
OXSR1 RELL1	O95747 Q8IUW5	0:0	hu.MAP2
MGST2 OXSR1 RELL1 RELL2	O95747 Q8IUW5 Q8NC24 Q99735	0:0:0:0	hu.MAP2
CRAT CYP2B6 RELL1 RELT STK39	P20813 P43155 Q8IUW5 Q969Z4 Q9UEW8	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	R SequencingMass spectrometry	12	33212158 41216884 29148239 27863537 32284825 39940641 39505756 40089067 35194965 32089743 37205098 34186243

Sequence, Structure & Domains8

Sequences

Length

271

Mass

29,340

Sequence

MAPRALPGSAVLAAAVFVGGAVSSPLVAPDNGSSRTLHSRTETTPSPSNDTGNGHPEYIAYALVPVFFIMGLFGVLICHLLKKKGYRCTTEAEQDIEEEKVEKIELNDSVNENSDTVGQIVHYIMKNEANADVLKAMVADNSLYDPESPVTPSTPGSPPVSPGPLSPGGTPGKHVCGHHLHTVGGVVERDVCHRCRHKRWHFIKPTNKSRESRPRRQGEVTVLSVGRFRVTKVEHKSNQKERRSLMSVSGAETVNGEVPATPVKRERSGTE

Domain & Motif Annotations

Compositional Bias

31..52; Polar residues; 155..165; Pro residues; 233..244; Basic and acidic residues

Coiled Coil

89..113

Region

28..53; Disordered; 145..173; Disordered; 233..271; Disordered

Protein Families

RELT family

Sequence Similarities

Belongs to the RELT family.

Clinical Relevance1

Antibody

HPA013377

Supporting Publications1

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available