Protein detail

TM139

Transmembrane protein 139

Entry name TM139	UniProt ID Q8IV31	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane protein 139

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

35..55; Helical

Transmembrane Count

Ensembl

ENSG00000178826

Entrez Gene Symbol

TMEM139

Gene Synonym

FLJ90586

Gene Description

Transmembrane protein 139

Chromosome

Position

143279957-143288048

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificFibro-adipogenic progenitorsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence12

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	RPS6KA3 TMEM139 ZMYM5	P51812 Q8IV31 Q9UJ78	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	3	40985879 37322475 38207106

Sequence, Structure & Domains5

Sequences

Length

216

Mass

23,729

Sequence

MVPMHLLGRLEKPLLLLCCASFLLGLALLGIKTDITPVAYFFLTLGGFFLFAYLLVRFLEWGLRSQLQSMQTESPGPSGNARDNEAFEVPVYEEAVVGLESQCRPQELDQPPPYSTVVIPPAPEEEQPSHPEGSRRAKLEQRRMASEGSMAQEGSPGRAPINLRLRGPRAVSTAPDLQSLAAVPTLEPLTPPPAYDVCFGHPDDDSVFYEDNWAPP

Domain & Motif Annotations

Compositional Bias

127..145; Basic and acidic residues

Region

104..163; Disordered

Clinical Relevance1

Antibody (2)

HPA036982 HPA036983

Supporting Publications2

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
37033249	Altered ureido protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men.	No abstract available