Protein detail

NUDC3

NudC domain-containing protein 3

Entry name NUDC3	UniProt ID Q8IVD9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

NudC domain-containing protein 3

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000015676

Entrez Gene Symbol

NUDCD3

Gene Synonym (2)

KIAA1068NudCL

Gene Description

NudC domain containing 3

Chromosome

Position

44379119-44490658

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificNeutrophilsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Dynein-2 complexcytoplasmic	DYNC2H1 DYNC2I1 DYNC2I2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT2B DYNLT3 NUDCD3	P51808 P63167 P63172 Q8IVD9 Q8NCM8 Q8TCX1 Q8TF09 Q8WVS4 Q8WW35 Q96EX3 Q96FJ2 Q9NP97	0:0:0:0:0:0:0:0:0:0:0:0	CORUM	CORUM:6236	25205765
	ARID1B CACNG2 CDC5L CPSF6 MED14 MED18 MED6 NUDCD3 PSME3IP1 SMARCA4 SMARCB1 SMARCC2 SMARCD1 SMARCE1 USP10	O60244 O75586 P51532 Q12824 Q14694 Q16630 Q8IVD9 Q8NFD5 Q8TAQ2 Q969G3 Q96GM5 Q99459 Q9BUE0 Q9GZU8 Q9Y698	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9062
	KLHL18 NUDCD3	O94889 Q8IVD9	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28240915

Sequence, Structure & Domains10

Sequences

Length

361

Mass

40,822

Sequence

METGAAELYDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLLRHPSDRMGFPPGAAQALVLQVFKTFDHMARQDDEKRRQELEEKIRRKEEEEAKTVSAAAAEKEPVPVPVQEIEIDSTTELDGHQEVEKVQPPGPVKEMAHGSQEAEAPGAVAGAAEVPREPPILPRIQEQFQKNPDSYNGAVRENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKVGEYWWNAILEGEEPIDIDKINKERSMATVDEEEQAVLDRLTFDYHQKLQGKPQSHELKVHEMLKKGWDAEGSPFRGQRFDPAMFNISPGAVQF

3D Structural Models

Turn

248..250

Helix

212..214

Beta Strand

179..185; 191..195; 198..204; 215..219; 221..229; 231..244; 252..255; 259..265; 267..270

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

87..97; Basic and acidic residues; 148..158; Low complexity

Domain (FT)

185..277; CS

Region

87..106; Disordered; 124..158; Disordered

Clinical Relevance4

Antibody (3)

HPA019136 HPA019528 HPA019529

Interaction Protein (8)

ENSG00000007168ENSG00000076321ENSG00000096060ENSG00000123444ENSG00000147231ENSG00000162517ENSG00000189091ENSG00000198642

Interaction Count

Interaction Dataset (3)

intact_biogridbiogrid_bioplexbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available