Protein detail

FMNL3

Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)

Entry name
FMNL3
UniProt ID
Q8IVF7
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000161791
Entrez Gene Symbol
FMNL3
Gene Synonym (3)
DKFZp762B245MGC45819WBP3
Gene Description
Formin like 3
Chromosome
12
Position
49636499-49708165
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
FMNL3 fluorescence
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
KEGG
hsa04820 Cytoskeleton in muscle cells
Reactome (8)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass Spectrometry133298282
Sequence, Structure & Domains

Sequences

Length
1,028
Mass
117,213
Sequence
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IVF7-1; Sequence=Displayed; Name=2; IsoId=Q8IVF7-2; Sequence=VSP_025892, VSP_025893; Name=3; IsoId=Q8IVF7-3; Sequence=VSP_025893
Alternative Sequence
152..202; Missing (in isoform 2); 999..1028; VLKSVPFTARTAKRGSRFFCDAAHHDESNC -> GLHCQPMVVRHQARSAAPPSGPPRAPGPH (in isoform 3 and isoform 2)

Domain & Motif Annotations

Compositional Bias
508..541; Pro residues
Domain (CC)
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Domain (FT)
26..472; GBD/FH3; 561..951; FH2; 986..1018; DAD
Region
493..541; Disordered
Protein Families
Formin homology family
Sequence Similarities
Belongs to the formin homology family.
Clinical Relevance
Antibody (2)
HPA002552HPA023201
Supporting Publications1
PMIDTitleRelated sentences
39702169iTRAQ proteomic analysis of exosomes derived from synovial fluid reveals disease patterns and potential biomarkers of Osteoarthritis.No related sentences available