Protein detail
P3H3
Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)
Protein symbol P3H3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)
Protein Class
EnzymesPredicted intracellular proteins
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GRCBHSU47926LEPREL2
Gene Description
Prolyl 3-hydroxylase 3
Chromosome
12
Position
6828407-6839847
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
736
Mass
81,837
Sequence
MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IVL6-1; Sequence=Displayed; Name=2; IsoId=Q8IVL6-2; Sequence=VSP_019352
Alternative Sequence
1..185; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
258..272; Acidic residues; 694..704; Acidic residues; 721..736; Basic and acidic residues
Repeat
37..70; TPR 1; 154..187; TPR 2; 216..249; TPR 3; 316..349; TPR 4
Motif
733..736; Prevents secretion from ER
Coiled Coil
681..709
Domain (FT)
561..675; Fe2OG dioxygenase
Region
253..275; Disordered; 689..736; Disordered
Protein Families
Leprecan family
Sequence Similarities
Belongs to the leprecan family.
Clinical Relevance
Antibody