Protein detail

P3H3

Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)

Entry name P3H3	UniProt ID Q8IVL6	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (3)

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Ensembl

ENSG00000110811

Entrez Gene Symbol

P3H3

Gene Synonym (3)

GRCBHSU47926LEPREL2

Gene Description

Prolyl 3-hydroxylase 3

Chromosome

Position

6828407-6839847

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificEarly spermatids

Function & Pathway6

Protein Function (3)

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	P3H3 P3H4	Q8IVL6 Q92791	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	32384937 30865381

Sequence, Structure & Domains13

Sequences

Length

736

Mass

81,837

Sequence

MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IVL6-1; Sequence=Displayed; Name=2; IsoId=Q8IVL6-2; Sequence=VSP_019352

Alternative Sequence

1..185; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

258..272; Acidic residues; 694..704; Acidic residues; 721..736; Basic and acidic residues

Repeat

37..70; TPR 1; 154..187; TPR 2; 216..249; TPR 3; 316..349; TPR 4

Motif

733..736; Prevents secretion from ER

Coiled Coil

681..709

Domain (FT)

561..675; Fe2OG dioxygenase

Region

253..275; Disordered; 689..736; Disordered

Protein Families

Leprecan family

Sequence Similarities

Belongs to the leprecan family.

Clinical Relevance2

Drugs

SERTRALINE HYDROCHLORIDE

Antibody

HPA043695

Supporting Publications1

PMID	Title	Abstract
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available