Protein detail
MISP
Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)
Entry name MISP | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
C19orf21CapriceDKFZp686H18209MISP1
Gene Description
Mitotic spindle positioning
Chromosome
19
Position
751112-764318
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M72 Pid nectin pathway
- M53 Pid integrin3 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MISP | AURKB | Q96GD4 | S | 348 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| MISP | AKT1 | P31749 | S | 156 | phosphorylation | PhosphoNetworks | |
| MISP | AKT1 | P31749 | T | 377 | phosphorylation | PhosphoNetworks | |
| MISP | AKT1 | P31749 | S | 394 | phosphorylation | PhosphoNetworks | |
| MISP | AKT1 | P31749 | S | 471 | phosphorylation | PhosphoNetworks | |
| MISP | EGF | P01133 | S | 474 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass Spectrometry（LC-MS/MS） | 1 | 33304478 |
Sequence, Structure & Domains
Sequences
Length
679
Mass
75,357
Sequence
MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCMGPEASGWGQDEPQTWPTDHRAQQGVQRQGVSYSVHAYTGQPSPRGLHSENREDEGWQVYRLGARDAHQGRPTWALRPEDGEDKEMKTYRLDAGDADPRRLCDLERERWAVIQGQAVRKSSTVATLQGTPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKGAPHSSPARGTPAGTTPGASQAPKAFNKPHLANGHVVPIKPQVKGVVREENKVRAVPTWASVQVVDDPGSLASVESPGTPKETPIEREIRLAQEREADLREQRGLRQATDHQELVEIPTRPLLTKLSLITAPRRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQEASKPPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVAEERRNALFPEVFSPTPDENSDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNAMAERWESRIYASEEDD
3D Structural Models
Domain & Motif Annotations
Compositional Bias
153..163; Polar residues; 360..371; Basic and acidic residues; 401..411; Low complexity; 472..482; Polar residues; 557..567; Basic and acidic residues; 583..593; Low complexity
Coiled Coil
545..569
Region
151..182; Disordered; 206..245; Disordered; 360..419; Disordered; 447..494; Disordered; 557..598; Disordered; 622..643; Disordered
Protein Families
MISP family
Sequence Similarities
Belongs to the MISP family.
Clinical Relevance
Interaction Protein
ENSG00000092820
Interaction Count
1
Interaction Dataset
intact_biogrid