Protein detail

SLIK4

SLIT and NTRK-like protein 4

Entry name SLIK4	UniProt ID Q8IW52	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

SLIT and NTRK-like protein 4

Protein Class

Predicted membrane proteins

Transmembrane

619..639; Helical

Transmembrane Count

Ensembl

ENSG00000179542

Entrez Gene Symbol

SLITRK4

Gene Synonym

DKFZp547M2010

Gene Description

SLIT and NTRK like family member 4

Chromosome

Position

143622790-143636101

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue Specificskeletal muscleCell SpecificBergmann gliaSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway6

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence33

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometry	8	33304478 32854315 32560723 33309826 31805958 38607062 38207106 39207047

Sequence, Structure & Domains7

Sequences

Length

837

Mass

94,331

Sequence

MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI

Domain & Motif Annotations

Repeat

60..81; LRR 1; 84..105; LRR 2; 108..129; LRR 3; 132..153; LRR 4; 156..177; LRR 5; 179..200; LRR 6; 378..399; LRR 7; 402..423; LRR 8; 426..447; LRR 9; 450..471; LRR 10; 474..495; LRR 11; 497..518; LRR 12

Domain (FT)

213..264; LRRCT 1; 333..375; LRRNT; 531..582; LRRCT 2

Protein Families

SLITRK family

Sequence Similarities

Belongs to the SLITRK family.

Clinical Relevance1

Antibody

HPA000431

Supporting Publications1

PMID	Title	Abstract
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available