Protein detail

SLIK4

SLIT and NTRK-like protein 4

Protein symbol SLIK4	UniProt ID Q8IW52	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Predicted membrane proteins

Basic Information

Protein Names

SLIT and NTRK-like protein 4

Protein Class

Predicted membrane proteins

Transmembrane

619..639; Helical

Transmembrane Count

Ensembl

ENSG00000179542

Entrez Gene Symbol

SLITRK4

Gene Synonym

DKFZp547M2010

Gene Description

SLIT and NTRK like family member 4

Chromosome

Position

143622790-143636101

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificBergmann gliaSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway

Cellular Component

Molecular Function

GO:0005515 protein binding

Biological Process

KEGG

Reactome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometry	8	33304478 32854315 32560723 33309826 31805958 38607062 38207106 39207047

Sequence, Structure & Domains

Sequences

Length

837

Mass

94,331

Sequence

MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI

3D Structural Models

Domain & Motif Annotations

Repeat

60..81; LRR 1; 84..105; LRR 2; 108..129; LRR 3; 132..153; LRR 4; 156..177; LRR 5; 179..200; LRR 6; 378..399; LRR 7; 402..423; LRR 8; 426..447; LRR 9; 450..471; LRR 10; 474..495; LRR 11; 497..518; LRR 12

Domain (FT)

213..264; LRRCT 1; 333..375; LRRNT; 531..582; LRRCT 2

Protein Families

SLITRK family

Sequence Similarities

Belongs to the SLITRK family.

Clinical Relevance

Antibody

HPA000431