Protein detail
CTL2
Choline transporter-like protein 2 (Solute carrier family 44 member 2)
Entry name CTL2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Choline transporter-like protein 2 (Solute carrier family 44 member 2)
Protein Class (4)
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
34..54; Helical; 233..253; Helical; 257..277; Helical; 316..336; Helical; 365..385; Helical; 458..480; Helical; 505..525; Helical; 564..584; Helical; 600..620; Helical; 639..659; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
CTL2
Gene Description
Solute carrier family 44 member 2
Chromosome
19
Position
10602457-10644557
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain SpecificleukocyteBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
Reactome (10)
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-168249 innate immune system
- R-hsa-556833 metabolism of lipids
- R-hsa-6798695 neutrophil degranulation
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9958517 slc mediated bile acid transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-1483191 synthesis of pc
- R-hsa-382551 transport of small molecules
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingFlow CytometryElisa | 1 | 37742368 |
Sequence, Structure & Domains7
Sequences
Length
706
Mass
80,124
Sequence
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYKGVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESRQCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
Alternative Products
Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; Synonyms=CTL2a, CTL2P2A; IsoId=Q8IWA5-1; Sequence=Displayed; Name=2; Synonyms=CTL2b, CTL2P2B; IsoId=Q8IWA5-2; Sequence=VSP_015431; Name=3; Synonyms=CTL2P1; IsoId=Q8IWA5-3; Sequence=VSP_041792
Alternative Sequence
1..12; MGDERPHYYGKH -> MEDERKNGAY (in isoform 3); 672..706; LEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES -> CEDLERNDGSQERPYFMSPELRDILLKGSAEEGKRAEAEE (in isoform 2)
Domain & Motif Annotations
Protein Families
CTL (choline transporter-like) family
Sequence Similarities
Belongs to the CTL (choline transporter-like) family.
Clinical Relevance5
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 24069378 | Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression. | We found that the large majority of the proteins identified in NB derived exosomes are present in Exocarta database including tetraspanins, fibronectin, heat shock proteins, MVB proteins, cytoskeleton-related proteins, prominin-1 (CD133), basigin (CD147) and B7-H3 (CD276). |