Protein detail

ARCH

tRNA-splicing ligase-activating factor archease (EC 2.7.7.-) (Zinc finger and BTB domain-containing opposite strand protein 8)

Entry name ARCH	UniProt ID Q8IWT0	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

tRNA-splicing ligase-activating factor archease (EC 2.7.7.-) (Zinc finger and BTB domain-containing opposite strand protein 8)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000176261

Entrez Gene Symbol

ZBTB8OS

Gene Synonym

ARCH

Gene Description

Zinc finger and BTB domain containing 8 opposite strand

Chromosome

Position

32600172-32650903

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specifictestis

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M118 Pid integrin a9b1 pathway
M165 Pid syndecan 4 pathway
M17 Pid notch pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
tRNA-splicing ligase complex	C2orf49 DDX1 FAM98A FAM98B RTCB RTRAF ZBTB8OS	Q52LJ0 Q8IWT0 Q8NCA5 Q92499 Q9BVC5 Q9Y224 Q9Y3I0	1:1:1:1:1:1:1	ComplexPortal	intact:EBI-26615168	21311021 24870230 14755292 24608264
	PWP1 ZBTB8OS	Q13610 Q8IWT0	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	28986585 32089743

Sequence, Structure & Domains

Sequences

Length

167

Mass

19,491

Sequence

MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI

Alternative Products

Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; IsoId=Q8IWT0-1; Sequence=Displayed; Name=2; IsoId=Q8IWT0-2; Sequence=VSP_024926; Name=3; IsoId=Q8IWT0-3; Sequence=VSP_062690

Alternative Sequence

1; M -> MKGGSRVSNPAVM (in isoform 3); 110..167; EVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI -> VGRRIFIVQAPSGNRSQSNNIFSNAGL (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Protein Families

Archease family

Sequence Similarities

Belongs to the archease family.

Clinical Relevance

Antibody

HPA046315