Protein detail
ARCH
tRNA-splicing ligase-activating factor archease (EC 2.7.7.-) (Zinc finger and BTB domain-containing opposite strand protein 8)
Entry name ARCH | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Essential proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
tRNA-splicing ligase-activating factor archease (EC 2.7.7.-) (Zinc finger and BTB domain-containing opposite strand protein 8)
Protein Class (2)
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ARCH
Gene Description
Zinc finger and BTB domain containing 8 opposite strand
Chromosome
1
Position
32600172-32650903
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization1
Tissue Specifictestis
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M118 Pid integrin a9b1 pathway
- M165 Pid syndecan 4 pathway
- M17 Pid notch pathway
Mediation Categories
Other mediation
Relations & Evidence6
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| tRNA-splicing ligase complex | C2orf49DDX1FAM98AFAM98BRTCBRTRAFZBTB8OS | Q52LJ0Q8IWT0Q8NCA5Q92499Q9BVC5Q9Y224Q9Y3I0 | 1:1:1:1:1:1:1 | ComplexPortal | intact:EBI-26615168 | 21311021248702301475529224608264 |
| PWP1ZBTB8OS | Q13610Q8IWT0 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains8
Sequences
Length
167
Mass
19,491
Sequence
MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=3; Name=1; IsoId=Q8IWT0-1; Sequence=Displayed; Name=2; IsoId=Q8IWT0-2; Sequence=VSP_024926; Name=3; IsoId=Q8IWT0-3; Sequence=VSP_062690
Alternative Sequence
1; M -> MKGGSRVSNPAVM (in isoform 3); 110..167; EVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI -> VGRRIFIVQAPSGNRSQSNNIFSNAGL (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Protein Families
Archease family
Sequence Similarities
Belongs to the archease family.
Clinical Relevance1
Antibody