Protein detail

SCN4B

Sodium channel regulatory subunit beta-4

Entry name SCN4B	UniProt ID Q8IWT1	EVMP confidence score 0.25
Supporting publications (n) 4	Transmembrane count 1	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium channel regulatory subunit beta-4

Protein Class (5)

Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Transmembrane

163..183; Helical

Transmembrane Count

Ensembl

ENSG00000177098

Entrez Gene Symbol

SCN4B

Gene Synonym

LQT10

Gene Description

Sodium voltage-gated channel beta subunit 4

Chromosome

Position

118133377-118152888

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted - unknown locationSecretome FunctionReceptor

Function & Pathway7

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (8)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence34

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Nav1.3 voltage-gated sodium channel complexSCN1B-SCN4B variant	SCN1B SCN3A SCN4B	Q07699 Q8IWT1 Q9NY46	1:1:1	ComplexPortal	intact:EBI-48430641	22473783 18688235 14755292 22992729
Nav1.4 voltage-gated sodium channel complexSCN1B-SCN4B variant	SCN1B SCN4A SCN4B	P35499 Q07699 Q8IWT1	1:1:1	ComplexPortal	intact:EBI-48430715PDB:6AGF	18688235 22992729 22473783 14755292 30190309
Nav1.8 voltage-gated sodium channel complexSCN1B-SCN4B variant	SCN10A SCN1B SCN4B	Q07699 Q8IWT1 Q9Y5Y9	1:1:1	ComplexPortal	intact:EBI-48431680	22473783 14755292 22992729
Nav1.9 voltage-gated sodium channel complexSCN1B-SCN4B variant	SCN11A SCN1B SCN4B	Q07699 Q8IWT1 Q9UI33	1:1:1	ComplexPortal	intact:EBI-48431841	22473783 14755292 22992729
	SCN4B	Q8IWT1	2	PDB	PDB:4mz3PDB:5xaw

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western BlottingImmunoelectron MicroscopyFlow Cytometry	1	38439112

Sequence, Structure & Domains14

Sequences

Length

228

Mass

24,969

Sequence

MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IWT1-1; Sequence=Displayed; Name=2; IsoId=Q8IWT1-2; Sequence=VSP_053913; Name=3; IsoId=Q8IWT1-3; Sequence=VSP_046971

Alternative Sequence

1..110; Missing (in isoform 2); 21..155; GLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRL -> V (in isoform 3)

3D Structural Models

Turn

58..60

Helix

123..125; 136..138

Beta Strand

32..34; 39..44; 49..51; 62..71; 76..86; 92..96; 101..103; 116..118; 127..135; 140..143; 147..152

3D Structure

Electron microscopy (1); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

203..213; Polar residues; 219..228; Basic and acidic residues

Domain (FT)

31..148; Ig-like C2-type

Region

200..228; Disordered

Protein Families

Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family

Sequence Similarities

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.

Clinical Relevance4

Disease Involvement (4)

Atrial fibrillationDisease variantFDA approved drug targetsLong QT syndrome

Drug Targets

FDA approved drug targets

Drugs

ZONISAMIDE

Antibody

HPA017293

Supporting Publications4

PMID	Title	Abstract
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available