Protein detail
SCN4B
Sodium channel regulatory subunit beta-4
Protein symbol SCN4B | UniProt ID | EVMP score 0.25 |
Frequency 4 | Transmembrane count 1 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium channel regulatory subunit beta-4
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Transmembrane
163..183; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
LQT10
Gene Description
Sodium voltage-gated channel beta subunit 4
Chromosome
11
Position
118133377-118152888
Frequency
4
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Nav1.3 voltage-gated sodium channel complexSCN1B-SCN4B variant | SCN1BSCN3ASCN4B | Q07699Q8IWT1Q9NY46 | 1:1:1 | ComplexPortal | intact:EBI-48430641 | 22473783186882351475529222992729 |
| Nav1.4 voltage-gated sodium channel complexSCN1B-SCN4B variant | SCN1BSCN4ASCN4B | P35499Q07699Q8IWT1 | 1:1:1 | ComplexPortal | intact:EBI-48430715PDB:6AGF | 1868823522992729224737831475529230190309 |
| Nav1.8 voltage-gated sodium channel complexSCN1B-SCN4B variant | SCN10ASCN1BSCN4B | Q07699Q8IWT1Q9Y5Y9 | 1:1:1 | ComplexPortal | intact:EBI-48431680 | 224737831475529222992729 |
| Nav1.9 voltage-gated sodium channel complexSCN1B-SCN4B variant | SCN11ASCN1BSCN4B | Q07699Q8IWT1Q9UI33 | 1:1:1 | ComplexPortal | intact:EBI-48431841 | 224737831475529222992729 |
| SCN4B | Q8IWT1 | 2 | PDB | PDB:4mz3PDB:5xaw |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Western BlottingImmunoelectron MicroscopyFlow Cytometry | 1 | 38439112 |
Sequence, Structure & Domains
Sequences
Length
228
Mass
24,969
Sequence
MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IWT1-1; Sequence=Displayed; Name=2; IsoId=Q8IWT1-2; Sequence=VSP_053913; Name=3; IsoId=Q8IWT1-3; Sequence=VSP_046971
Alternative Sequence
1..110; Missing (in isoform 2); 21..155; GLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRL -> V (in isoform 3)
3D Structural Models
Turn
58..60
Helix
123..125; 136..138
Beta Strand
32..34; 39..44; 49..51; 62..71; 76..86; 92..96; 101..103; 116..118; 127..135; 140..143; 147..152
3D Structure
Electron microscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
203..213; Polar residues; 219..228; Basic and acidic residues
Domain (FT)
31..148; Ig-like C2-type
Region
200..228; Disordered
Protein Families
Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
Sequence Similarities
Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family.
Clinical Relevance
Disease Involvement
Atrial fibrillationDisease variantFDA approved drug targetsLong QT syndrome
Drug Targets
FDA approved drug targets
Drugs
Antibody