Protein detail

LRC8A

Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)

Protein symbol LRC8A	UniProt ID Q8IWT6	EVMP score 0.25
Frequency 1	Transmembrane count 4	Protein classification

Basic Information

Protein Names

Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)

Protein Function

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Transporters:Transporter channels and pores
Potential drug targets

Transmembrane

24..47; Helical; Name=1; 124..142; Helical; Name=2; 265..286; Helical; Name=3; 317..341; Helical; Name=4

Transmembrane Count

Ensembl

ENSG00000136802

Entrez Gene Symbol

LRRC8A

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificT-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificMAIT T-cellBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionImmunity

Function & Pathway

Protein Function

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Transporters:Transporter channels and pores
Potential drug targets

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M5883 Naba secreted factors
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LRRC8A	RPS6KA5	O75582	S	217	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

18 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
volume_regulated_anion	ion_channel	HGNC	No	Yes	No	No	No
ion_channel	ion_channel	HGNC	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
LRRC8A-LRRC8D complex	LRRC8A LRRC8D	Q7L1W4 Q8IWT6	0:0	CORUM	CORUM:6582	26824658
LRRC8A-LRRC8E complex	LRRC8A LRRC8E	Q6NSJ5 Q8IWT6	0:0	CORUM	CORUM:6583	26824658
	LRRC8A	Q8IWT6	6	PDB	PDB:5zsuPDB:7xzhPDB:6djb

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass Spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

810

Mass

94,199

Sequence

MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWVTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA

3D Structural Models

Turn

8..10; 300..302; 345..349; 370..372; 566..568; 781..783

Helix

4..7; 15..20; 23..48; 103..116; 120..145; 147..165; 167..171; 234..254; 259..285; 286..288; 315..344; 356..359; 373..380; 384..390; 391..394; 396..410; 413..419; 440..444; 463..467; 485..493; 505..507; 510..514; 538..542; 560..565; 587..589; 608..612; 630..637; 656..660; 679..683; 702..706; 725..729; 748..752; 771..775; 788..792; 796..806

Beta Strand

53..56; 58..61; 294..296; 306..311; 428..434; 450..455; 458..460; 473..478; 496..501; 520..525; 548..553; 571..575; 595..600; 618..620; 643..645; 666..668; 689..691; 712..714; 735..737; 758..760

3D Structure

Electron microscopy (8)

Domain & Motif Annotations

Repeat

399..422; LRR 1; 423..445; LRR 2; 447..468; LRR 3; 469..492; LRR 4; 493..515; LRR 5; 518..542; LRR 6; 543..565; LRR 7; 567..589; LRR 8; 590..613; LRR 9; 615..637; LRR 10; 639..661; LRR 11; 662..684; LRR 12; 686..707; LRR 13; 708..730; LRR 14; 732..753; LRR 15; 754..776; LRR 16; 778..801; LRR 17

Motif

706..707; Di-leucine motif

Domain (CC)

The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.; DOMAIN: The di-leucine motif is required for lysosomal localization.; DOMAIN: The cytoplasmic N-terminus preceding the first transmembrane (residues 1-22) regulates volume-regulated anion channel (VRAC) conductance, ion permeability and inactivation gating.

Protein Families

LRRC8 family

Sequence Similarities

Belongs to the LRRC8 family.

Clinical Relevance

Interaction Protein

ENSG00000197147

Interaction Count

Interaction Dataset

intact_biogrid