Protein detail
LAX1
Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)
Entry name LAX1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Lymphocyte transmembrane adapter 1 (Linker for activation of X cells) (Membrane-associated adapter protein LAX)
Protein Class
Predicted membrane proteins
Transmembrane
38..58; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ20340LAX
Gene Description
Lymphocyte transmembrane adaptor 1
Chromosome
1
Position
203765177-203776372
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LAX1 | SYK | P43405 | Y | 268 | phosphorylation | PhosphoSite | |
| LAX1 | SYK | P43405 | Y | 294 | phosphorylation | PhosphoSite | |
| LAX1 | SYK | P43405 | Y | 373 | phosphorylation | PhosphoSite | |
| LAX1 | SYK | P43405 | Y | 193 | phosphorylation | PhosphoSite | |
| LAX1 | LCK | P06239 | Y | 373 | phosphorylation | PhosphoSite | |
| LAX1 | LCK | P06239 | Y | 193 | phosphorylation | PhosphoSite | |
| LAX1 | LCK | P06239 | Y | 268 | phosphorylation | PhosphoSite | |
| LAX1 | LCK | P06239 | Y | 294 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KSYK | P43405 | LAX1 | Q8IWV1 | Yes | Yes | No | SPIKEWangPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDSPIKE_LCPhosphoSitePhosphoSite_ProtMapper | SPIKE:12359715SIGNOR:12359715PhosphoSite:12359715HPRD:12359715SPIKE_LC:12359715 |
| LCK | P06239 | LAX1 | Q8IWV1 | Yes | Yes | No | WangiPTMnetSIGNORPhosphoPointProtMapperHPRDSPIKE_LCSPIKEPhosphoSite_ProtMapper | HPRD:12359715SPIKE:12359715SIGNOR:12359715SPIKE_LC:12359715 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
398
Mass
44,085
Sequence
MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IWV1-1; Sequence=Displayed; Name=2; IsoId=Q8IWV1-2; Sequence=VSP_016641; Name=3; IsoId=Q8IWV1-3; Sequence=VSP_046972
Alternative Sequence
1..76; Missing (in isoform 2); 1..29; MDGVTPTLSTIRGRTLESSTLHVTPRSLD -> MRSHFLQWALATS (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
303..318; Polar residues; 320..329; Basic and acidic residues
Region
228..261; Disordered; 298..330; Disordered; 347..398; Disordered