Protein detail

SCUB3

Signal peptide, CUB and EGF-like domain-containing protein 3

Entry name SCUB3	UniProt ID Q8IX30	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Signal peptide, CUB and EGF-like domain-containing protein 3

Protein Class (3)

Disease related genesHuman disease related genesPredicted secreted proteins

Protein Function (3)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations

Ensembl

ENSG00000146197

Entrez Gene Symbol

SCUBE3

Gene Synonym (2)

CEGF3FLJ34743

Gene Description

Signal peptide, CUB domain and EGF like domain containing 3

Chromosome

Position

35213956-35253079

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificAdrenal medulla cells

Function & Pathway6

Protein Function (3)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

Reactome (2)

Mediation Categories

Other mediation

Relations & Evidence10

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	Matrisome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
ligand	ligand	Matrisome	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture	Mass spectrometryMass spectrometry\|Western blotting\|FACSFACSMass spectrometry [LTQ-FT Ultra]Small R sequencing (Illumi HiSeq 2000 (Solexa)Western blotting	64	33327484 33315384 33269813 33003586 32760666 32642575 32054015 31894881 31820036 31806995 31786017 31676071 31485223 31473497 31184411 31048929 30909497 30893511 30108515 33450254 33456364 33627162 33738083 33823894 33827783 33851819 34016170 34060205 34120145 34246124 34407878 34744733 34885085 35485158 35903297 36108271 36183939 36463112 36472010 16229685 22772984 23230278 23767874 24733759 25857718 25928805 26754424 26938523 27419629 27564521 27758876 28895255 28928832 29143228 35328491 36183939 36463112 36472010 37600336 38612385 38902710 38942135 39166055 39273689

Sequence, Structure & Domains6

Sequences

Length

993

Mass

109,282

Sequence

MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IX30-1; Sequence=Displayed; Name=2; IsoId=Q8IX30-2; Sequence=VSP_052167

Alternative Sequence

237; I -> IGERRLEQHIPTQAVSN (in isoform 2)

Domain & Motif Annotations

Domain (FT)

29..69; EGF-like 1; calcium-binding; 70..111; EGF-like 2; calcium-binding; 112..148; EGF-like 3; calcium-binding; 157..198; EGF-like 4; 199..237; EGF-like 5; 238..276; EGF-like 6; 277..317; EGF-like 7; calcium-binding; 318..356; EGF-like 8; calcium-binding; 357..398; EGF-like 9; calcium-binding; 804..916; CUB

Clinical Relevance2

Disease Involvement (2)

Disease variantDwarfism

Antibody

HPA040606

Supporting Publications1

PMID	Title	Abstract
32284825	Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.	No abstract available