Protein detail

SCUB3

Signal peptide, CUB and EGF-like domain-containing protein 3

Entry name
SCUB3
UniProt ID
Q8IX30
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted secreted proteins
Basic Information
Protein Names
Signal peptide, CUB and EGF-like domain-containing protein 3
Protein Class (3)
Disease related genesHuman disease related genesPredicted secreted proteins
Protein Function (3)
  • Disease related genes
  • Predicted secreted proteins
  • Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
ENSG00000146197
Entrez Gene Symbol
SCUBE3
Gene Synonym (2)
CEGF3FLJ34743
Gene Description
Signal peptide, CUB domain and EGF like domain containing 3
Chromosome
6
Position
35213956-35253079
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificAdrenal medulla cells
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Predicted secreted proteins
  • Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
Reactome (2)
Mediation Categories
Other mediation
Relations & Evidence10

Ligand-Receptor Signaling (9)

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYesYes
ecmecmOmniPathYesYes
secretedsecretedUniProt_keywordYes
secretedsecretedUniProt_locationYes
secretedsecretedHPA_secretomeYes
secretedsecretedMatrisomeYes
secretedsecretedOmniPathYes
ligandligandMatrisomeYesYes
ligandligandOmniPathYesYes

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity CaptureMass spectrometryMass spectrometry|Western blotting|FACSFACSMass spectrometry [LTQ-FT Ultra]Small R sequencing (Illumi HiSeq 2000 (Solexa)Western blotting6433327484333153843326981333003586327606663264257532054015318948813182003631806995317860173167607131485223314734973118441131048929309094973089351130108515334502543345636433627162337380833382389433827783338518193401617034060205341201453424612434407878347447333488508535485158359032973610827136183939364631123647201016229685227729842323027823767874247337592585771825928805267544242693852327419629275645212775887628895255289288322914322835328491361839393646311236472010376003363861238538902710389421353916605539273689
Sequence, Structure & Domains

Sequences

Length
993
Mass
109,282
Sequence
MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IX30-1; Sequence=Displayed; Name=2; IsoId=Q8IX30-2; Sequence=VSP_052167
Alternative Sequence
237; I -> IGERRLEQHIPTQAVSN (in isoform 2)

Domain & Motif Annotations

Domain (FT)
29..69; EGF-like 1; calcium-binding; 70..111; EGF-like 2; calcium-binding; 112..148; EGF-like 3; calcium-binding; 157..198; EGF-like 4; 199..237; EGF-like 5; 238..276; EGF-like 6; 277..317; EGF-like 7; calcium-binding; 318..356; EGF-like 8; calcium-binding; 357..398; EGF-like 9; calcium-binding; 804..916; CUB
Clinical Relevance
Disease Involvement (2)
Disease variantDwarfism
Related Diseases
Dwarfism
Antibody
HPA040606
Supporting Publications1
PMIDTitleRelated sentences
32284825Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.No related sentences available