Protein detail
SCUB3
Signal peptide, CUB and EGF-like domain-containing protein 3
Protein symbol SCUB3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Signal peptide, CUB and EGF-like domain-containing protein 3
Protein Class
Disease related genesHuman disease related genesPredicted secreted proteins
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Gene Synonym
CEGF3FLJ34743
Gene Description
Signal peptide, CUB domain and EGF like domain containing 3
Chromosome
6
Position
35213956-35253079
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAdrenal medulla cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | Matrisome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ligand | ligand | Matrisome | Yes | No | Yes | No | No |
| ligand | ligand | OmniPath | Yes | No | Yes | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture | Mass spectrometryMass spectrometry|Western blotting|FACSFACSMass spectrometry [LTQ-FT Ultra]Small R sequencing (Illumi HiSeq 2000 (Solexa)Western blotting | 64 | 33327484333153843326981333003586327606663264257532054015318948813182003631806995317860173167607131485223314734973118441131048929309094973089351130108515334502543345636433627162337380833382389433827783338518193401617034060205341201453424612434407878347447333488508535485158359032973610827136183939364631123647201016229685227729842323027823767874247337592585771825928805267544242693852327419629275645212775887628895255289288322914322835328491361839393646311236472010376003363861238538902710389421353916605539273689 |
Sequence, Structure & Domains
Sequences
Length
993
Mass
109,282
Sequence
MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IX30-1; Sequence=Displayed; Name=2; IsoId=Q8IX30-2; Sequence=VSP_052167
Alternative Sequence
237; I -> IGERRLEQHIPTQAVSN (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
29..69; EGF-like 1; calcium-binding; 70..111; EGF-like 2; calcium-binding; 112..148; EGF-like 3; calcium-binding; 157..198; EGF-like 4; 199..237; EGF-like 5; 238..276; EGF-like 6; 277..317; EGF-like 7; calcium-binding; 318..356; EGF-like 8; calcium-binding; 357..398; EGF-like 9; calcium-binding; 804..916; CUB
Clinical Relevance
Disease Involvement
Disease variantDwarfism
Antibody