Protein detail

GLT12

Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)

Entry name GLT12	UniProt ID Q8IXK2	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (6)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Transmembrane

20..37; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000119514

Entrez Gene Symbol

GALNT12

Gene Synonym

GalNAc-T12

Gene Description

Polypeptide N-acetylgalactosaminyltransferase 12

Chromosome

Position

98807670-98850081

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificnaive CD8 T-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (6)

Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (6)

Mediation Categories (2)

Clinical-translation mediationMetabolism mediation

Relations & Evidence15

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GALNT12 HPX	P02790 Q8IXK2	0:0	hu.MAP
GALNT12	Q8IXK2	2	PDB	PDB:6pxu
GALNT12 GALNT4 PIANP	Q8IXK2 Q8IYJ0 Q8N4A0	0:0:0	hu.MAP2
GALNT12 GALNT4 LAMP3 MARCHF5 PIANP	Q8IXK2 Q8IYJ0 Q8N4A0 Q9NX47 Q9UQV4	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	37	33330567 33252112 33135636 32855524 32648717 32343772 32166281 31199456 30621731 29981499 29740045 29632728 11150547 33669497 34006621 34071980 34407878 34439311 34440851 35234046 35294531 35846887 36334903 36462328 36526691 36531939 26820481 27211553 27537259 28469765 36982991 37438583 37568802 37600336 38084936 38902710 39166055

Sequence, Structure & Domains14

Sequences

Length

581

Mass

66,938

Sequence

MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IXK2-1; Sequence=Displayed; Name=2; IsoId=Q8IXK2-2; Sequence=VSP_011217

Alternative Sequence

1..309; Missing (in isoform 2)

3D Structural Models

Turn

75..78; 132..134; 262..264; 542..545; 554..556

Helix

88..101; 105..108; 123..127; 149..162; 165..167; 181..183; 185..191; 207..218; 238..247; 292..297; 319..324; 338..348; 376..387; 389..391; 392..398; 400..404; 411..419; 425..431; 484..486; 527..529; 570..572

Beta Strand

61..65; 138..146; 168..175; 197..201; 221..226; 229..233; 251..260; 276..279; 285..288; 315..318; 334..337; 352..364; 445..454; 457..460; 464..467; 475..478; 488..490; 496..498; 500..503; 505..508; 517..520; 531..533; 537..541; 546..551; 560..564; 573..579

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.; DOMAIN: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

Domain (FT)

445..577; Ricin B-type lectin

Region

43..67; Disordered; 135..244; Catalytic subdomain A; 304..366; Catalytic subdomain B

Protein Families (2)

Glycosyltransferase 2 family
GalNAc-T subfamily

Sequence Similarities

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Clinical Relevance2

Disease Involvement

Disease variant

Antibody (2)

HPA048292 HPA071076

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available