Protein detail
GLT12
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
Protein symbol GLT12 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Transmembrane
20..37; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GalNAc-T12
Gene Description
Polypeptide N-acetylgalactosaminyltransferase 12
Chromosome
9
Position
98807670-98850081
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificnaive CD8 T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 37 | 33330567332521123313563632855524326487173234377232166281311994563062173129981499297400452963272811150547336694973400662134071980344078783443931134440851352340463529453135846887363349033646232836526691365319392682048127211553275372592846976536982991374385833756880237600336380849363890271039166055 |
Sequence, Structure & Domains
Sequences
Length
581
Mass
66,938
Sequence
MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IXK2-1; Sequence=Displayed; Name=2; IsoId=Q8IXK2-2; Sequence=VSP_011217
Alternative Sequence
1..309; Missing (in isoform 2)
3D Structural Models
Turn
75..78; 132..134; 262..264; 542..545; 554..556
Helix
88..101; 105..108; 123..127; 149..162; 165..167; 181..183; 185..191; 207..218; 238..247; 292..297; 319..324; 338..348; 376..387; 389..391; 392..398; 400..404; 411..419; 425..431; 484..486; 527..529; 570..572
Beta Strand
61..65; 138..146; 168..175; 197..201; 221..226; 229..233; 251..260; 276..279; 285..288; 315..318; 334..337; 352..364; 445..454; 457..460; 464..467; 475..478; 488..490; 496..498; 500..503; 505..508; 517..520; 531..533; 537..541; 546..551; 560..564; 573..579
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.; DOMAIN: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
Domain (FT)
445..577; Ricin B-type lectin
Region
43..67; Disordered; 135..244; Catalytic subdomain A; 304..366; Catalytic subdomain B
Protein Families
- Glycosyltransferase 2 family
- GalNAc-T subfamily
Sequence Similarities
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.