Protein detail

T183A

Transmembrane protein 183A

Entry name T183A	UniProt ID Q8IXX5	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Transmembrane protein 183A

Transmembrane

300..320; Helical

Transmembrane Count

Ensembl

ENSG00000163444

Entrez Gene Symbol

TMEM183A

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificEarly spermatidsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway5

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Canonical Pathways (2)

M137 Pid vegf vegfr pathway
M226 Pid vegfr1 pathway

Mediation Categories

Other mediation

Relations & Evidence12

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

Page 2 of 2Previous

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	40784529 37922300

Sequence, Structure & Domains8

Sequences

Length

376

Mass

42,826

Sequence

MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDAQEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IXX5-1; Sequence=Displayed; Name=2; IsoId=Q8IXX5-2; Sequence=VSP_015084

Alternative Sequence

237..376; Missing (in isoform 2)

Domain & Motif Annotations

Region

1..20; Disordered; 100..127; Disordered

Protein Families

TMEM183 family

Sequence Similarities

Belongs to the TMEM183 family.

Supporting Publications1

PMID	Title	Abstract
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available