Protein detail

SMAP1

Stromal membrane-associated protein 1

Protein symbol SMAP1	UniProt ID Q8IYB5	EVMP score 0.50
Frequency 3	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Stromal membrane-associated protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000112305

Entrez Gene Symbol

SMAP1

Gene Synonym

FLJ13159SMAP-1

Gene Description

Small ArfGAP 1

Chromosome

Position

70667776-70862011

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificEndometrial ciliated cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04144 Endocytosis

Canonical Pathways

M88 Pid cd8 tcr pathway
M100 Pid shp2 pathway
M10 Pid bcr 5pathway

Mediation Categories

Adhesion and uptake mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AKR1E2 DNM1L HIKESHI MTHFD1 SMAP1	O00429 P11586 Q53FT3 Q8IYB5 Q96JD6	0:0:0:0:0	hu.MAP2
AP1B1 AP1G1 AP1S2 CLINT1 CLTB CLTC GGA2 GGA3 HGS SMAP1 TOM1 TOM1L1 UBC WRAP73	O14964 O43747 O60784 O75674 P09497 P0CG48 P56377 Q00610 Q10567 Q14677 Q8IYB5 Q9NZ52 Q9P2S5 Q9UJY4	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8891
AKR1E2 ARF5 COQ3 MTHFD1 SMAP1	P11586 P84085 Q8IYB5 Q96JD6 Q9NZJ6	0:0:0:0:0	hu.MAP2
SMAP1 UBE2N UBE2V2	P61088 Q15819 Q8IYB5	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryELISA	5	32795414 26775013 24700864 35085587 40311616

Sequence, Structure & Domains

Sequences

Length

467

Mass

50,386

Sequence

MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SMAP1A; IsoId=Q8IYB5-1; Sequence=Displayed; Name=2; Synonyms=SMAP1B; IsoId=Q8IYB5-2; Sequence=VSP_018502; Name=3; IsoId=Q8IYB5-3; Sequence=VSP_018502, VSP_018503

Alternative Sequence

139..165; Missing (in isoform 2 and isoform 3); 424..467; MNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK -> IMQKGDAVLQHSISAIYWPMTRWLKCPLVDESADGWHEYQ (in isoform 3)

3D Structural Models

Turn

10..15; 46..49; 65..67

Helix

17..26; 28..30; 54..63; 80..88; 90..97; 98..100; 112..123; 132..134

Beta Strand

34..36; 43..45; 73..76

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

145..155; Polar residues; 160..185; Basic and acidic residues; 192..204; Basic and acidic residues; 413..438; Polar residues; 446..467; Low complexity

Motif

218..222; Interaction with clathrin heavy chains

Zinc Finger

33..56; C4-type

Domain (FT)

18..136; Arf-GAP

Region

145..224; Disordered; 408..467; Disordered

Clinical Relevance

Antibody

HPA030574