Protein detail

SMAP1

Stromal membrane-associated protein 1

Entry name SMAP1	UniProt ID Q8IYB5	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Stromal membrane-associated protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000112305

Entrez Gene Symbol

SMAP1

Gene Synonym (2)

FLJ13159SMAP-1

Gene Description

Small ArfGAP 1

Chromosome

Position

70667776-70862011

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificEndometrial ciliated cells

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04144 Endocytosis

Canonical Pathways (3)

M88 Pid cd8 tcr pathway
M100 Pid shp2 pathway
M10 Pid bcr 5pathway

Mediation Categories (3)

Adhesion and uptake mediationImmune mediationMetabolism mediation

Relations & Evidence16

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AKR1E2 DNM1L HIKESHI MTHFD1 SMAP1	O00429 P11586 Q53FT3 Q8IYB5 Q96JD6	0:0:0:0:0	hu.MAP2
AP1B1 AP1G1 AP1S2 CLINT1 CLTB CLTC GGA2 GGA3 HGS SMAP1 TOM1 TOM1L1 UBC WRAP73	O14964 O43747 O60784 O75674 P09497 P0CG48 P56377 Q00610 Q10567 Q14677 Q8IYB5 Q9NZ52 Q9P2S5 Q9UJY4	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8891
AKR1E2 ARF5 COQ3 MTHFD1 SMAP1	P11586 P84085 Q8IYB5 Q96JD6 Q9NZJ6	0:0:0:0:0	hu.MAP2
SMAP1 UBE2N UBE2V2	P61088 Q15819 Q8IYB5	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryELISA	5	32795414 26775013 24700864 35085587 40311616

Sequence, Structure & Domains14

Sequences

Length

467

Mass

50,386

Sequence

MATRSCREKAQKLNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKNAIAITNISSSDAPLQPLVSSPSLQAAVDKNKLEKEKEKKKEEKKREKEPEKPAKPLTAEKLQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLSQMNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SMAP1A; IsoId=Q8IYB5-1; Sequence=Displayed; Name=2; Synonyms=SMAP1B; IsoId=Q8IYB5-2; Sequence=VSP_018502; Name=3; IsoId=Q8IYB5-3; Sequence=VSP_018502, VSP_018503

Alternative Sequence

139..165; Missing (in isoform 2 and isoform 3); 424..467; MNQQMAGMSISSATPTAGFGQPSSTTAGWSGSSSGQTLSTQLWK -> IMQKGDAVLQHSISAIYWPMTRWLKCPLVDESADGWHEYQ (in isoform 3)

3D Structural Models

Turn

10..15; 46..49; 65..67

Helix

17..26; 28..30; 54..63; 80..88; 90..97; 98..100; 112..123; 132..134

Beta Strand

34..36; 43..45; 73..76

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

145..155; Polar residues; 160..185; Basic and acidic residues; 192..204; Basic and acidic residues; 413..438; Polar residues; 446..467; Low complexity

Motif

218..222; Interaction with clathrin heavy chains

Zinc Finger

33..56; C4-type

Domain (FT)

18..136; Arf-GAP

Region

145..224; Disordered; 408..467; Disordered

Clinical Relevance1

Antibody

HPA030574

Supporting Publications3

PMID	Title	Abstract
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available
41201090	Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma.	No abstract available