Protein detail

TEFF1

Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain)

Entry name TEFF1	UniProt ID Q8IYR6	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

331..351; Helical

Transmembrane Count

Ensembl

ENSG00000241697

Entrez Gene Symbol

TMEFF1

Gene Synonym (3)

C9orf2CT120.1H7365

Gene Description

Transmembrane protein with EGF like and two follistatin like domains 1

Chromosome

Position

100473149-100577636

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain SpecificpericyteSecretome LocationSecreted to extracellular matrixSecretome FunctionDevelopmental protein

Function & Pathway5

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component

GO:0005886 plasma membrane

Biological Process (3)

Canonical Pathways

M195 Pid cmyb pathway

Mediation Categories

Other mediation

Relations & Evidence26

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
other_receptor_family	receptor	HPMR	No	Yes	No	Yes	No
transferrin	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
DHRS2 FGF2 STEAP3 TMEFF1	P09038 Q13268 Q658P3 Q8IYR6	0:0:0:0	hu.MAP
BCS1L DHRS2 FGF2 TMEFF1	P09038 Q13268 Q8IYR6 Q9Y276	0:0:0:0	hu.MAP
FGF2 STEAP3 TMEFF1	P09038 Q658P3 Q8IYR6	0:0:0	hu.MAP2
STEAP3 TMEFF1	Q658P3 Q8IYR6	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	3	38731868 26775013 40098346

Sequence, Structure & Domains10

Sequences

Length

380

Mass

40,934

Sequence

MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IYR6-1; Sequence=Displayed; Name=2; IsoId=Q8IYR6-2; Sequence=VSP_024959

Alternative Sequence

1..65; MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGKSINCS -> MLPEQLYFLQSPPEEEPEYHPDASAQ (in isoform 2)

Domain & Motif Annotations

Compositional Bias

366..380; Polar residues

Domain (FT)

98..145; Kazal-like 1; 189..237; Kazal-like 2; 271..311; EGF-like

Region

359..380; Disordered

Protein Families

Tomoregulin family

Sequence Similarities

Belongs to the tomoregulin family.

Clinical Relevance5

Disease Involvement

Disease variant

Antibody

HPA051501

Interaction Protein

ENSG00000157540

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available