Protein detail

PHAR4

Phosphatase and actin regulator 4

Protein symbol PHAR4	UniProt ID Q8IZ21	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Phosphatase and actin regulator 4

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000204138

Entrez Gene Symbol

PHACTR4

Gene Synonym

FLJ13171PPP1R124

Gene Description

Phosphatase and actin regulator 4

Chromosome

Position

28369582-28500364

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificErythrocyte progenitors

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M134 Pid tcr ras pathway
M199 Pid p38 mk2 pathway
M1718 Sig il4receptor in b lyphocytes

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
IFIT1 IFIT2 IFIT3 PHACTR4 RAB9B	O14879 P09913 P09914 Q8IZ21 Q9NP90	0:0:0:0:0	hu.MAP2
IFIT2 PHACTR4	P09913 Q8IZ21	0:0	hu.MAP2
PHACTR4 RAB9B	Q8IZ21 Q9NP90	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry [LTQ-FT Ultra]Mass spectrometryWestern blotting\|Flow cytometryFlow cytometry	29	33338939 32944191 31806995 31746532 31143515 29679665 29416092 34016744 34108659 34147721 34218049 34239692 34841476 36162554 36353645 24887393 27728760 27819324 28086180 28607485 29143228 29188480 35078498 36107309 36454036 37384818 38431093 38439112 38749193

Sequence, Structure & Domains

Sequences

Length

702

Mass

78,211

Sequence

MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IZ21-1; Sequence=Displayed; Name=2; IsoId=Q8IZ21-2; Sequence=VSP_025437; Name=3; IsoId=Q8IZ21-3; Sequence=VSP_025436; Name=4; IsoId=Q8IZ21-4; Sequence=VSP_039730, VSP_039731

Alternative Sequence

1..16; Missing (in isoform 3); 1..5; MEDPF -> MGQADVSRPVNPDAV (in isoform 2); 6; E -> DFSREPWNSRGSRPAHYRARHGPGQCGSRRHNTSYQKEEQVLRLWQDLQALEMEEKKK (in isoform 4); 7..702; Missing (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

72..84; Basic and acidic residues; 106..120; Polar residues; 147..156; Polar residues; 163..173; Pro residues; 233..250; Low complexity; 301..318; Polar residues; 342..362; Pro residues; 484..497; Polar residues; 508..518; Acidic residues

Repeat

63..88; RPEL 1; 583..608; RPEL 2; 621..646; RPEL 3

Region

1..37; Disordered; 72..194; Disordered; 222..363; Disordered; 469..536; Disordered; 592..615; Disordered

Protein Families

Phosphatase and actin regulator family

Sequence Similarities

Belongs to the phosphatase and actin regulator family.

Clinical Relevance

Antibody

HPA028985