Protein detail

S38A6

Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1)

Protein symbol S38A6	UniProt ID Q8IZM9	EVMP score 0.38
Frequency 1	Transmembrane count 11	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Solute carrier family 38 member 6 (Amino acid transporter SLC38A6) (N-system amino acid transporter 1) (NAT-1)

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

42..62; Helical; 85..105; Helical; 111..131; Helical; 170..190; Helical; 191..211; Helical; 250..270; Helical; 288..308; Helical; 327..347; Helical; 371..391; Helical; 394..414; Helical; 431..451; Helical

Transmembrane Count

Ensembl

ENSG00000139974

Entrez Gene Symbol

SLC38A6

Gene Synonym

NAT-1

Gene Description

Solute carrier family 38 member 6

Chromosome

Position

60981114-61114316

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEndometrial luminal cells

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	2	39408670 34265469

Sequence, Structure & Domains

Sequences

Length

456

Mass

50,929

Sequence

MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFDWINK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZM9-1; Sequence=Displayed; Name=2; IsoId=Q8IZM9-2; Sequence=VSP_029563

Alternative Sequence

431..456; AFVLLIFGILVGNFSLALIIFDWINK -> GLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTGRDTMEMCTQRKGHARTQQEGNCLQAKGRGLRRTKRVHTLILHFPTSRTVSK (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families

Amino acid/polyamine transporter 2 family

Sequence Similarities

Belongs to the amino acid/polyamine transporter 2 family.

Clinical Relevance

Antibody

HPA018508