Protein detail

ABI1

Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)

Entry name ABI1	UniProt ID Q8IZP0	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

Cancer-related genesDisease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Ensembl

ENSG00000136754

Entrez Gene Symbol

ABI1

Gene Synonym

ABI-1E3B1SSH3BP1

Gene Description

Abl interactor 1

Chromosome

Position

26746593-26861087

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins
Cancer-related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M160 Pid avb3 integrin pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

20 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ABI1	MAPK3	P27361	S	225	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:21419341 ProtMapper:21419341
ABI1	MAPK3	P27361	S	410	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	S	183	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	S	267	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	T	394	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	S	392	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	S	216	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	MAPK3	P27361	T	265	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABI1	CDK1	P06493	S	216	phosphorylation	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:23354023 SIGNOR:21900237
ABI1	CCNB1	P14635	S	216	phosphorylation	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:23354023 SIGNOR:21900237

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Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTEN	P60484	ABI1	Q8IZP0	Yes	No	Yes	SIGNOR	SIGNOR:32673396
ABL1	P00519	ABI1	Q8IZP0	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperdbPTMHINTLit-BM-17HPRDIntActWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperAdhesomeSPIKE_LCSPIKE	IntAct:20598684 SPIKE_LC:17145710 HPRD:9010225 ProtMapper:18328268 dbPTM:19534553 HPRD:17101133 Lit-BM-17:20598684 HINT:17101133 IntAct:11418237 IntAct:9593709 HPRD:12672821 ProtMapper:21320496 HINT:11418237 ProtMapper:26428302 PhosphoSite:18328268 SPIKE:18328268 Lit-BM-17:11418237 Lit-BM-17:18328268 SPIKE_LC:20841568 Adhesome:11418237 Adhesome:21320496 dbPTM:18083107 Adhesome:11163214 HINT:18328268 Adhesome:18328268 IntAct:18328268 dbPTM:17389395 Adhesome:12672821 Adhesome:9010225 Adhesome:7590237 Adhesome:20598684 IntAct:17101133 Adhesome:17101133 HINT:9593709 Lit-BM-17:17101133 HINT:12672821 Lit-BM-17:9593709 SPIKE_LC:17101133 Adhesome:12591740 Adhesome:9593709 Lit-BM-17:9010225 SPIKE_LC:18328268 Lit-BM-17:12672821 dbPTM:18328268 PhosphoSite:20598684 HPRD:8943360 SIGNOR:21320496 SPIKE:20841568 HPRD:9593709 HPRD:11418237
ABI1	Q8IZP0	ABL1	P00519	Yes	Yes	No	AdhesomeSIGNORProtMapperREACH_ProtMapperHPRDHINTSignaLink3IntActSPIKE_LCLit-BM-17	IntAct:20598684 SPIKE_LC:17145710 HPRD:9010225 HPRD:17101133 Lit-BM-17:20598684 HINT:17101133 IntAct:11418237 IntAct:9593709 HPRD:12672821 HINT:11418237 Lit-BM-17:11418237 Lit-BM-17:18328268 Adhesome:11418237 Adhesome:21320496 Adhesome:11163214 HINT:18328268 Adhesome:18328268 IntAct:18328268 ProtMapper:23740246 Adhesome:12672821 Adhesome:9010225 Adhesome:7590237 Adhesome:20598684 IntAct:17101133 Adhesome:17101133 HINT:9593709 Lit-BM-17:17101133 SIGNOR:9010225 HINT:12672821 Lit-BM-17:9593709 SignaLink3:23331499 SPIKE_LC:17101133 Adhesome:12591740 Adhesome:9593709 Lit-BM-17:9010225 Lit-BM-17:12672821 SignaLink3:9010225 HPRD:8943360 HPRD:9593709 HPRD:11418237
ABI1	Q8IZP0	CBL	P22681	Yes	Yes	No	DOMINOAdhesomeNetPathSIGNORSPIKE_LCSPIKE	SPIKE_LC:18594017 NetPath:17395426 SPIKE:18594017 Adhesome:17395426 DOMINO:17395426 SIGNOR:17395426
MK01	P28482	ABI1	Q8IZP0	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21419341 PhosphoSite:21900237 PhosphoSite:21419341 SIGNOR:21419341 PhosphoSite:17855441 PhosphoSite:19917258
CDK1	P06493	ABI1	Q8IZP0	Yes	No	Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:23354023 SIGNOR:21900237 ProtMapper:21900237
DTBP1	Q96EV8	ABI1	Q8IZP0	Yes	Yes	No	SIGNOR	SIGNOR:20531346
MK03	P27361	ABI1	Q8IZP0	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	SIGNOR:21419341 ProtMapper:21419341
	COMPLEX:P06493_P14635	ABI1	Q8IZP0	Yes	No	Yes	SIGNOR	SIGNOR:21900237

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ABI1 CDC123	O75794 Q8IZP0	0:0	Havugimana2012	Havugimana2012:C_45
ABI1 NCKAP1 RYK UBC	P0CG48 P34925 Q8IZP0 Q9Y2A7	1:1:1:1	CompleatCFinder	Compleat:HC9210
ABI1 BRK1 NHS	Q6T4R5 Q8IZP0 Q8WUW1	0:0:0	hu.MAP
ABI1 BRK1 NHS SYAP1	Q6T4R5 Q8IZP0 Q8WUW1 Q96A49	0:0:0:0	hu.MAP
ABI1 CYFIP1 NCKAP1	Q7L576 Q8IZP0 Q9Y2A7	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry；Olink	2	25471207 40098346

Sequence, Structure & Domains

Sequences

Length

508

Mass

55,081

Sequence

MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD

Alternative Products

Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8IZP0-1; Sequence=Displayed; Name=2; Synonyms=long, B48; IsoId=Q8IZP0-2; Sequence=VSP_010749, VSP_010750, VSP_010751, VSP_010752; Name=3; IsoId=Q8IZP0-3; Sequence=VSP_010750, VSP_010752; Name=4; IsoId=Q8IZP0-4; Sequence=VSP_010750, VSP_010751, VSP_010752; Name=5; IsoId=Q8IZP0-5; Sequence=VSP_010749, VSP_010750; Name=6; IsoId=Q8IZP0-6; Sequence=VSP_010750, VSP_010751; Name=7; Synonyms=4; IsoId=Q8IZP0-7; Sequence=VSP_010750, VSP_010751, VSP_010754, VSP_010755; Name=8; Synonyms=5; IsoId=Q8IZP0-8; Sequence=VSP_010750, VSP_010751, VSP_010754, VSP_010752; Name=9; Synonyms=2; IsoId=Q8IZP0-9; Sequence=VSP_010750; Name=10; Synonyms=B30; IsoId=Q8IZP0-10; Sequence=VSP_010749, VSP_010750, VSP_010751, VSP_010754, VSP_010752, VSP_010753; Name=11; IsoId=Q8IZP0-11; Sequence=VSP_043403, VSP_010750, VSP_010751, VSP_010754, VSP_010752, VSP_010753; Name=12; IsoId=Q8IZP0-12; Sequence=VSP_044604, VSP_010752

Alternative Sequence

38; I -> IQRHGFAVLLCLLSNSWP (in isoform 12); 96..159; Missing (in isoform 11); 154..158; Missing (in isoform 2, isoform 5 and isoform 10); 274..300; Missing (in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11); 301; Missing (in isoform 2, isoform 4, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11); 302..359; Missing (in isoform 7, isoform 8, isoform 10 and isoform 11); 360..388; Missing (in isoform 2, isoform 3, isoform 4, isoform 8, isoform 10, isoform 11 and isoform 12); 360; I -> V (in isoform 7); 389; I -> V (in isoform 10 and isoform 11)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

161..175; Polar residues; 222..235; Polar residues; 248..258; Low complexity; 278..290; Pro residues; 307..322; Polar residues; 337..347; Polar residues; 393..403; Pro residues; 410..419; Pro residues

Domain (CC)

The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.

Domain (FT)

45..107; t-SNARE coiled-coil homology; 446..505; SH3

Region

18..79; Required for binding to WASF1; 159..290; Disordered; 306..375; Disordered; 388..421; Disordered

Protein Families

ABI family

Sequence Similarities

Belongs to the ABI family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

IMATINIB NILOTINIB DASATINIB ANHYDROUS PONATINIB

Antibody

CAB008375 HPA068407

Interaction Protein

ENSG00000055163ENSG00000061676ENSG00000085733ENSG00000097007ENSG00000112290ENSG00000115904ENSG00000141837ENSG00000158092ENSG00000158195ENSG00000175866ENSG00000273749

Interaction Count

Interaction Dataset

intact_biogridintact_biogrid_opencellbiogrid_opencell