Protein detail

AGRG2

Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) [Cleaved into: Adhesion G-protein coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G-protein coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]

Protein symbol
AGRG2
UniProt ID
Q8IZP9
EVMP score
0.50
Frequency
1
Transmembrane count
7
Protein classification
Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) [Cleaved into: Adhesion G-protein coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G-protein coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]
Protein Class
Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
  • G-protein coupled receptors:Family 2 (B) receptors
  • Transporters
  • Potential drug targets
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of genital organs
Transmembrane
628..648; Helical; Name=1; 668..688; Helical; Name=2; 694..714; Helical; Name=3; 738..758; Helical; Name=4; 790..810; Helical; Name=5; 835..855; Helical; Name=6; 858..878; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000173698
Entrez Gene Symbol
ADGRG2
Gene Synonym
EDDM6GPR64HE6TM7LN2
Gene Description
Adhesion G protein-coupled receptor G2
Chromosome
X
Position
18989307-19122637
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
  • G-protein coupled receptors:Family 2 (B) receptors
  • Transporters
  • Potential drug targets
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of genital organs
Cellular Component
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

45 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
adhesionreceptorSurfaceomeNoYesNoYesNo
class_b2_adhesionreceptorGPCRdbNoYesNoYesNo
class_b2_adhesion_adhesionreceptorGPCRdbNoYesNoYesNo
class_b2_adhesion_adhesion_adgrgreceptorGPCRdbNoYesNoYesNo
receptorreceptorOmniPathNoYesNoYesNo
extracellularextracellularHPMRNoNoNoYesNo
extracellularextracellularOmniPathNoNoNoYesNo
intracellularintracellularGO_IntercellNoNoNoYesNo
intracellularintracellularOmniPathNoNoNoYesNo
adhesionadhesionHGNCYesYesNoYesNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass spectrometry23330447840189497
Sequence, Structure & Domains

Sequences

Length
1,017
Mass
111,593
Sequence
MVFSVRQCGHVGRTEEVLLTFKIFLVIICLHVVLVTSLEEDTDNSSLSPPPAKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNASGVKPQRNICNLSSICNDSAFFRGEIMFQYDKESTVPQNQHITNGTLTGVLSLSELKRSELNKTLQTLSETYFIMCATAEAQSTLNCTFTIKLNNTMNACAVIAALERVKIRPMEHCCCSVRIPCPSSPEELEKLQCDLQDPIVCLADHPRGPPFSSSQSIPVVPRATVLSQVPKATSFAEPPDYSPVTHNVPSPIGEIQPLSPQPSAPIASSPAIDMPPQSETISSPMPQTHVSGTPPPVKASFSSPTVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRLLHSPPDMLAPLAQRLLKVVDDIGLQLNFSNTTISLTSPSLALAVIRVNASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFETPALFQDPSLENLSLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNASTERNGVSFSVQNGDVCLHDFTGKQHMFNEKEDSCNGKGRMALRRTSKRGSLHFIEQM
Alternative Products
Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Long splice variant; IsoId=Q8IZP9-1; Sequence=Displayed; Name=2; IsoId=Q8IZP9-2; Sequence=VSP_009791; Name=3; Synonyms=d1; IsoId=Q8IZP9-3; Sequence=VSP_009792; Name=4; Synonyms=24; IsoId=Q8IZP9-4; Sequence=VSP_009793; Name=5; Synonyms=23; IsoId=Q8IZP9-5; Sequence=VSP_009794; Name=6; Synonyms=d3; IsoId=Q8IZP9-6; Sequence=VSP_009795; Name=7; Synonyms=d2; IsoId=Q8IZP9-7; Sequence=VSP_009796; Name=8; Synonyms=21; IsoId=Q8IZP9-8; Sequence=VSP_009797; Name=9; Synonyms=Delta exon 28; IsoId=Q8IZP9-9; Sequence=VSP_009798; Name=10; IsoId=Q8IZP9-10; Sequence=VSP_009792, VSP_009793, VSP_054522
Alternative Sequence
51..66; Missing (in isoform 3 and isoform 10); 52..101; AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> EVETTSLNDVTLSLLPSNET (in isoform 7); 52..101; AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> DVTLSLLPSNET (in isoform 8); 52..75; Missing (in isoform 5); 65..67; Missing (in isoform 2); 68..101; EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> DVTLSLLPSNET (in isoform 6); 88..101; Missing (in isoform 4 and isoform 10); 474..562; Missing (in isoform 10); 906..956; Missing (in isoform 9)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
308..320; Low complexity; 321..335; Polar residues; 344..366; Polar residues
Domain (CC)
The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist (PubMed:33303626). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation (By similarity). On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling (By similarity).
Domain (FT)
462..619; GAIN-B
Region
301..366; Disordered; 570..619; GPS; 608..619; Stachel; 918..939; Disordered
Protein Families
  • G-protein coupled receptor 2 family
  • Adhesion G-protein coupled receptor (ADGR) subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Antibody
HPA001478HPA050029