Protein detail

AGRG2

Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) [Cleaved into: Adhesion G-protein coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G-protein coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]

Entry name
AGRG2
UniProt ID
Q8IZP9
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
7
Protein classification
Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6) [Cleaved into: Adhesion G-protein coupled receptor G2, N-terminal fragment (ADGRG2 N-terminal fragment); Adhesion G-protein coupled receptor G2, C-terminal fragment (ADGRG2 C-terminal fragment)]
Protein Class (7)
Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (6)
  • G-protein coupled receptors:Family 2 (B) receptors
  • Transporters
  • Potential drug targets
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of genital organs
Transmembrane
628..648; Helical; Name=1; 668..688; Helical; Name=2; 694..714; Helical; Name=3; 738..758; Helical; Name=4; 790..810; Helical; Name=5; 835..855; Helical; Name=6; 858..878; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000173698
Entrez Gene Symbol
ADGRG2
Gene Synonym (4)
EDDM6GPR64HE6TM7LN2
Gene Description
Adhesion G protein-coupled receptor G2
Chromosome
X
Position
18989307-19122637
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (6)
  • G-protein coupled receptors:Family 2 (B) receptors
  • Transporters
  • Potential drug targets
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of genital organs
Cellular Component (6)
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence46

Ligand-Receptor Signaling (45)

45 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneRamilowski_locationYes
transmembranetransmembraneOmniPathYes
plasma_membraneplasma_membraneUniProt_locationYes
apical_cell_membraneplasma_membraneUniProt_locationYes
plasma_membraneplasma_membraneOmniPathYes
plasma_membrane_transmembraneplasma_membrane_transmembraneCSPAYes
plasma_membrane_transmembraneplasma_membrane_transmembraneHPMRYes
plasma_membrane_transmembraneplasma_membrane_transmembraneOmniPathYes
cell_surfacecell_surfaceSurfaceomeYes
cell_surfacecell_surfaceOmniPathYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass spectrometry23330447840189497
Sequence, Structure & Domains

Sequences

Length
1,017
Mass
111,593
Sequence
MVFSVRQCGHVGRTEEVLLTFKIFLVIICLHVVLVTSLEEDTDNSSLSPPPAKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNASGVKPQRNICNLSSICNDSAFFRGEIMFQYDKESTVPQNQHITNGTLTGVLSLSELKRSELNKTLQTLSETYFIMCATAEAQSTLNCTFTIKLNNTMNACAVIAALERVKIRPMEHCCCSVRIPCPSSPEELEKLQCDLQDPIVCLADHPRGPPFSSSQSIPVVPRATVLSQVPKATSFAEPPDYSPVTHNVPSPIGEIQPLSPQPSAPIASSPAIDMPPQSETISSPMPQTHVSGTPPPVKASFSSPTVSAPANVNTTSAPPVQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGEMINQVSRLLHSPPDMLAPLAQRLLKVVDDIGLQLNFSNTTISLTSPSLALAVIRVNASSFNTTTFVAQDPANLQVSLETQAPENSIGTITLPSSLMNNLPAHDMELASRVQFNFFETPALFQDPSLENLSLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNASTERNGVSFSVQNGDVCLHDFTGKQHMFNEKEDSCNGKGRMALRRTSKRGSLHFIEQM
Alternative Products
Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=Long splice variant; IsoId=Q8IZP9-1; Sequence=Displayed; Name=2; IsoId=Q8IZP9-2; Sequence=VSP_009791; Name=3; Synonyms=d1; IsoId=Q8IZP9-3; Sequence=VSP_009792; Name=4; Synonyms=24; IsoId=Q8IZP9-4; Sequence=VSP_009793; Name=5; Synonyms=23; IsoId=Q8IZP9-5; Sequence=VSP_009794; Name=6; Synonyms=d3; IsoId=Q8IZP9-6; Sequence=VSP_009795; Name=7; Synonyms=d2; IsoId=Q8IZP9-7; Sequence=VSP_009796; Name=8; Synonyms=21; IsoId=Q8IZP9-8; Sequence=VSP_009797; Name=9; Synonyms=Delta exon 28; IsoId=Q8IZP9-9; Sequence=VSP_009798; Name=10; IsoId=Q8IZP9-10; Sequence=VSP_009792, VSP_009793, VSP_054522
Alternative Sequence
51..66; Missing (in isoform 3 and isoform 10); 52..101; AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> EVETTSLNDVTLSLLPSNET (in isoform 7); 52..101; AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> DVTLSLLPSNET (in isoform 8); 52..75; Missing (in isoform 5); 65..67; Missing (in isoform 2); 68..101; EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS -> DVTLSLLPSNET (in isoform 6); 88..101; Missing (in isoform 4 and isoform 10); 474..562; Missing (in isoform 10); 906..956; Missing (in isoform 9)

Domain & Motif Annotations

Compositional Bias
308..320; Low complexity; 321..335; Polar residues; 344..366; Polar residues
Domain (CC)
The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist (PubMed:33303626). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation (By similarity). On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling (By similarity).
Domain (FT)
462..619; GAIN-B
Region
301..366; Disordered; 570..619; GPS; 608..619; Stachel; 918..939; Disordered
Protein Families (2)
  • G-protein coupled receptor 2 family
  • Adhesion G-protein coupled receptor (ADGR) subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Antibody (2)
HPA001478HPA050029
Supporting Publications1
PMIDTitleRelated sentences
38037300Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.No related sentences available