Protein detail
CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)
Protein symbol CKLF4 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 4 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
59..79; Helical; 85..105; Helical; 123..143; Helical; 151..171; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
CKLFSF4
Gene Description
CKLF like MARVEL transmembrane domain containing 4
Chromosome
16
Position
66614750-66696743
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CKLF4 | Q8IZR5 | PD1L1 | Q9NZQ7 | Yes | Yes | No | SIGNOR | SIGNOR:28813410 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
234
Mass
25,828
Sequence
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IZR5-1; Sequence=Displayed; Name=2; IsoId=Q8IZR5-2; Sequence=VSP_008261; Name=3; IsoId=Q8IZR5-3; Sequence=VSP_008260, VSP_008261
Alternative Sequence
34..62; Missing (in isoform 3); 209..234; Missing (in isoform 2 and isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..11; Acidic residues; 15..25; Low complexity
Domain (FT)
49..176; MARVEL
Region
1..38; Disordered
Protein Families
Chemokine-like factor family
Sequence Similarities
Belongs to the chemokine-like factor family.