Protein detail
ABCA7
Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter)
Entry name ABCA7 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count 15 | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
22..42; Helical; 550..570; Helical; 593..613; Helical; 626..646; Helical; 655..675; Helical; 687..707; Helical; 727..747; Helical; 849..869; Helical; 1243..1263; Helical; 1538..1558; Helical; 1584..1604; Helical; 1621..1641; Helical; 1649..1669; Helical; 1683..1703; Helical; 1729..1749; Helical
Transmembrane Count
15
Ensembl
Entrez Gene Symbol
Gene Synonym
ABCX
Gene Description
ATP binding cassette subfamily A member 7
Chromosome
19
Position
1039997-1065572
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificesophagusCell SpecificAlveolar cells type 1
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component (11)
- GO:0000139 Golgi membrane
- GO:0001891 phagocytic cup
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0030054 cell junction
- GO:0031901 early endosome membrane
- GO:0032587 ruffle membrane
- GO:0043231 intracellular membrane-bounded organelle
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Molecular Function (9)
- GO:0005524 ATP binding
- GO:0005548 phospholipid transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0034188 apolipoprotein A-I receptor activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0090554 phosphatidylcholine floppase activity
- GO:0090556 phosphatidylserine floppase activity
- GO:0140328 floppase activity
- GO:0140359 ABC-type transporter activity
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence31
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| abc | transporter | DGIdb | No | Yes | No | Yes | No |
| transporter | transporter | DGIdb | No | Yes | No | Yes | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ABCA7 | Q8IZY2 | APOA1 | P02647 | Yes | Yes | No | SIGNOR | SIGNOR:12917409 |
Sequence, Structure & Domains14
Sequences
Length
2,146
Mass
234,350
Sequence
MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Type 1; IsoId=Q8IZY2-1; Sequence=Displayed; Name=2; Synonyms=Type 2; IsoId=Q8IZY2-2; Sequence=VSP_020701, VSP_020702
Alternative Sequence
1..138; Missing (in isoform 2); 139..166; AQPQPTKQSPLEPPMLDVAELLTSLLRT -> MVCLGTGQSAGPLVSVQNHCPPCGLSPQ (in isoform 2)
3D Structural Models
Turn
36..38; 126..129; 216..219; 342..346; 387..389; 404..406; 430..432; 492..495; 547..549; 556..558; 583..585; 653..656; 666..668; 683..686; 843..846; 880..882; 913..916; 931..934; 955..957; 966..969; 985..988; 1083..1085; 1105..1107; 1111..1113; 1122..1128; 1216..1219; 1241..1243; 1312..1315; 1440..1442; 1689..1692; 1694..1696; 1729..1732; 1858..1860; 2079..2082; 2093..2096
Helix
3..19; 24..30; 31..33; 39..43; 62..64; 67..74; 101..113; 116..125; 177..193; 200..207; 220..223; 265..274; 278..291; 302..316; 317..320; 323..336; 348..351; 377..382; 390..399; 418..429; 497..500; 503..519; 541..544; 552..555; 559..574; 579..582; 589..599; 602..605; 611..616; 625..632; 640..643; 645..647; 657..665; 669..675; 693..696; 698..704; 730..742; 748..754; 847..854; 876..879; 898..907; 917..926; 944..948; 951..953; 972..984; 998..1003; 1022..1029; 1075..1082; 1108..1110; 1114..1121; 1139..1150; 1221..1234; 1244..1256; 1293..1304; 1325..1331; 1387..1393; 1395..1398; 1401..1403; 1431..1439; 1452..1463; 1477..1479; 1482..1495; 1521..1531; 1534..1548; 1550..1558; 1565..1569; 1576..1604; 1619..1630; 1632..1637; 1648..1666; 1678..1688; 1698..1718; 1733..1739; 1743..1754; 1834..1841; 1862..1867; 1885..1892; 1901..1912; 1914..1916; 1929..1939; 1958..1971; 1986..1990; 2009..2015; 2028..2041; 2063..2065; 2070..2076; 2097..2101
Beta Strand
49..51; 82..84; 89..92; 130..132; 294..297; 338..341; 412..414; 434..438; 462..467; 470..473; 528..531; 537..539; 608..610; 635..639; 687..692; 705..708; 710..712; 718..721; 723..727; 758..760; 862..864; 959..962; 989..991; 1009..1012; 1015..1018; 1034..1038; 1090..1094; 1099..1102; 1131..1135; 1236..1238; 1278..1283; 1354..1356; 1374..1381; 1415..1418; 1445..1451; 1472..1475; 1510..1514; 1561..1564; 1612..1618; 1638..1641; 1675..1677; 1823..1825; 1830..1833; 1924..1928; 1994..1996; 2020..2025; 2046..2051; 2054..2059; 2066..2069; 2085..2090
3D Structure
Electron microscopy (6)
Domain & Motif Annotations
Compositional Bias
1048..1066; Basic and acidic residues
Domain (FT)
807..1038; ABC transporter 1; 1793..2025; ABC transporter 2
Region
1048..1072; Disordered; 1185..1209; Disordered; 2104..2146; Disordered
Protein Families (2)
- ABC transporter superfamily
- ABCA family
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCA family.
Clinical Relevance2
Disease Involvement (3)
Alzheimer diseaseAmyloidosisNeurodegeneration
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 28240915 | Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy. | No abstract available |