Protein detail

APCD1

Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein)

Entry name APCD1	UniProt ID Q8J025	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein)

Protein Function (3)

Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Transmembrane

493..512; Helical

Transmembrane Count

Ensembl

ENSG00000154856

Entrez Gene Symbol

APCDD1

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificmedium spiny neuron

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Skin diseases:Skin and soft tissue diseases
Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function (3)

Biological Process (3)

KEGG

hsa04310 Wnt signaling pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence37

Ligand-Receptor Signaling (36)

36 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	39408670 38037300

Sequence, Structure & Domains6

Sequences

Length

514

Mass

58,797

Sequence

MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR

Domain & Motif Annotations

Region

438..460; Disordered

Protein Families

APCDD1 family

Sequence Similarities

Belongs to the APCDD1 family.

Clinical Relevance1

Drugs

NULL

Supporting Publications1

PMID	Title	Abstract
37707657	Expression of CD13 and CD26 on extracellular vesicles in canine seminal plasma: preliminary results.	No abstract available