Protein detail
CADM3
Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)
Entry name CADM3 | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Transmembrane
331..351; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BIgRFLJ10698IGSF4BNecl-1NECL1SynCAM3TSLL1
Gene Description
Cell adhesion molecule 3
Chromosome
1
Position
159171609-159203313
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificthyroid glandBrain Regional Specificchoroid plexusCell SpecificVascular endothelial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| nectin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37704750 |
Sequence, Structure & Domains
Sequences
Length
398
Mass
43,300
Sequence
MGAPAASLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDPSPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGQSGGDDKKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N126-1; Sequence=Displayed; Name=2; IsoId=Q8N126-2; Sequence=VSP_017221; Name=3; IsoId=Q8N126-3; Sequence=VSP_022008
Alternative Sequence
29; D -> DGYWQEQDLELGTLAPLDEAISSTVWSSPDMLASQ (in isoform 2); 185..231; GKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLY -> D (in isoform 3)
3D Structural Models
Helix
102..104
Beta Strand
38..41; 46..51; 60..63; 69..72; 83..88; 90..97; 106..112; 114..116; 118..127
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The cytoplasmic region mediates interaction with EPB41L1, DLG3, PALS2 and CASK.
Domain (FT)
25..126; Ig-like V-type; 130..228; Ig-like C2-type 1; 233..315; Ig-like C2-type 2
Region
367..398; Disordered
Protein Families
Nectin family
Sequence Similarities
Belongs to the nectin family.