Protein detail
GBRG1
Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)
Protein symbol GBRG1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification FDA approved drug targetsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)
Protein Class
FDA approved drug targetsPredicted membrane proteins
Protein Function
FDA approved drug targets:Small molecule drugs
Transmembrane
274..294; Helical; 301..320; Helical; 329..349; Helical; 445..465; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Gamma-aminobutyric acid type A receptor subunit gamma1
Chromosome
4
Position
46035769-46124054
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
465
Mass
53,595
Sequence
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
3D Structural Models
Domain & Motif Annotations
Domain (CC)
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRG1 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
PADSEVONILLORAZEPAMCHLORDIAZEPOXIDE HYDROCHLORIDEGANAXOLONEESTAZOLAMSEVOFLURANETHIOPENTAL SODIUMCLORAZEPATEBUTABARBITAL SODIUMACAMPROSATE CALCIUMCENOBAMATECINOLAZEPAMETHCHLORVYNOLMIDAZOLAM HYDROCHLORIDEBREXANOLONEFLURAZEPAMNITRAZEPAMCLOBAZAMTHIAMYLAL SODIUMCHLORDIAZEPOXIDEMETHOHEXITAL SODIUMMETHAQUALONE HYDROCHLORIDETEMAZEPAMALPRAZOLAMFLUMAZENILPENTOBARBITAL SODIUMISOFLURANEPAGOCLONEMETHAQUALONEQUAZEPAMTRIAZOLAMDIMDAZENILHALAZEPAMFLUDIAZEPAMBUTALBITALDIAZEPAMFLUNITRAZEPAMESZOPICLONETETRAZEPAMTRICLOFOS SODIUMREMIMAZOLAMDESFLURANETOPIRAMATEMETHYPRYLONOXAZEPAMPRAZEPAMCLORAZEPATE DIPOTASSIUMADINAZOLAMCLONAZEPAMCHLORMETHIAZOLEGABOXADOLETIFOXINEHALOTHANEPRIMIDONETALBUTALMEPROBAMATERESEQUINILABP-700ETOMIDATEMETHOXYFLURANEENFLURANELOREDIPLONCLOTIAZEPAMADIPIPLONOCINAPLONBROMAZEPAMZURANOLONEREMIMAZOLAM BESYLATE[3H]AZIETOMIDATEFLURAZEPAM HYDROCHLORIDECIPEPOFOLMETHARBITALETAZOLATEDARIGABATGLUTETHIMIDEPROPOFOLSECOBARBITAL SODIUM