Protein detail

GBRG1

Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)

Entry name GBRG1	UniProt ID Q8N1C3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification FDA approved drug targetsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)

Protein Class (2)

FDA approved drug targetsPredicted membrane proteins

Protein Function

FDA approved drug targets:Small molecule drugs

Transmembrane

274..294; Helical; 301..320; Helical; 329..349; Helical; 445..465; Helical

Transmembrane Count

Ensembl

ENSG00000163285

Entrez Gene Symbol

GABRG1

Gene Description

Gamma-aminobutyric acid type A receptor subunit gamma1

Chromosome

Position

46035769-46124054

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway6

Protein Function

FDA approved drug targets:Small molecule drugs

Cellular Component (9)

Molecular Function (6)

Biological Process (3)

KEGG (7)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence29

Ligand-Receptor Signaling (27)

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
cys_loop	transporter	Surfaceome	No	Yes	No	No	No
channels	transporter	Surfaceome	No	Yes	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
ligand_gated	ion_channel	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GABRG1 GABRG2	P18507 Q8N1C3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingFlow cytometryMORPH	4	21835908 38173016 38762017 39166055

Sequence, Structure & Domains6

Sequences

Length

465

Mass

53,595

Sequence

MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL

Domain & Motif Annotations

Domain (CC)

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Protein Families (3)

Ligand-gated ion channel (TC 1.A.9) family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
GABRG1 sub-subfamily

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.

Clinical Relevance4

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (77)

PADSEVONIL LORAZEPAM CHLORDIAZEPOXIDE HYDROCHLORIDE GANAXOLONE ESTAZOLAM SEVOFLURANE THIOPENTAL SODIUM CLORAZEPATE BUTABARBITAL SODIUM ACAMPROSATE CALCIUM CENOBAMATE CINOLAZEPAM ETHCHLORVYNOL MIDAZOLAM HYDROCHLORIDE BREXANOLONE FLURAZEPAM NITRAZEPAM CLOBAZAM THIAMYLAL SODIUM CHLORDIAZEPOXIDE METHOHEXITAL SODIUM METHAQUALONE HYDROCHLORIDE TEMAZEPAM ALPRAZOLAM FLUMAZENIL PENTOBARBITAL SODIUM ISOFLURANE PAGOCLONE METHAQUALONE QUAZEPAM TRIAZOLAM DIMDAZENIL HALAZEPAM FLUDIAZEPAM BUTALBITAL DIAZEPAM FLUNITRAZEPAM ESZOPICLONE TETRAZEPAM TRICLOFOS SODIUM REMIMAZOLAM DESFLURANE TOPIRAMATE METHYPRYLON OXAZEPAM PRAZEPAM CLORAZEPATE DIPOTASSIUM ADINAZOLAM CLONAZEPAM CHLORMETHIAZOLE GABOXADOL ETIFOXINE HALOTHANE PRIMIDONE TALBUTAL MEPROBAMATE RESEQUINIL ABP-700 ETOMIDATE METHOXYFLURANE ENFLURANE LOREDIPLON CLOTIAZEPAM ADIPIPLON OCINAPLON BROMAZEPAM ZURANOLONE REMIMAZOLAM BESYLATE [3H]AZIETOMIDATE FLURAZEPAM HYDROCHLORIDE CIPEPOFOL METHARBITAL ETAZOLATE DARIGABAT GLUTETHIMIDE PROPOFOL SECOBARBITAL SODIUM

Antibody (2)

HPA035622 HPA058102

Supporting Publications1

PMID	Title	Abstract
37563857	Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications.	No abstract available