Protein detail
GBRG1
Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)
Entry name GBRG1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification FDA approved drug targetsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) (GABAAR subunit gamma-1)
Protein Class (2)
FDA approved drug targetsPredicted membrane proteins
Protein Function
FDA approved drug targets:Small molecule drugs
Transmembrane
274..294; Helical; 301..320; Helical; 329..349; Helical; 445..465; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Gamma-aminobutyric acid type A receptor subunit gamma1
Chromosome
4
Position
46035769-46124054
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
FDA approved drug targets:Small molecule drugs
Cellular Component (9)
Molecular Function (6)
Biological Process (3)
KEGG (7)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | OmniPath | |||||
| transporter | transporter | Surfaceome | Yes | ||||
| cys_loop | transporter | Surfaceome | Yes | ||||
| channels | transporter | Surfaceome | Yes | ||||
| ion_channel | ion_channel | DGIdb | Yes | ||||
| ligand_gated | ion_channel | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes |
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Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
465
Mass
53,595
Sequence
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
Domain & Motif Annotations
Domain (CC)
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families (3)
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRG1 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (77)
PADSEVONILLORAZEPAMCHLORDIAZEPOXIDE HYDROCHLORIDEGANAXOLONEESTAZOLAMSEVOFLURANETHIOPENTAL SODIUMCLORAZEPATEBUTABARBITAL SODIUMACAMPROSATE CALCIUMCENOBAMATECINOLAZEPAMETHCHLORVYNOLMIDAZOLAM HYDROCHLORIDEBREXANOLONEFLURAZEPAMNITRAZEPAMCLOBAZAMTHIAMYLAL SODIUMCHLORDIAZEPOXIDEMETHOHEXITAL SODIUMMETHAQUALONE HYDROCHLORIDETEMAZEPAMALPRAZOLAMFLUMAZENILPENTOBARBITAL SODIUMISOFLURANEPAGOCLONEMETHAQUALONEQUAZEPAMTRIAZOLAMDIMDAZENILHALAZEPAMFLUDIAZEPAMBUTALBITALDIAZEPAMFLUNITRAZEPAMESZOPICLONETETRAZEPAMTRICLOFOS SODIUMREMIMAZOLAMDESFLURANETOPIRAMATEMETHYPRYLONOXAZEPAMPRAZEPAMCLORAZEPATE DIPOTASSIUMADINAZOLAMCLONAZEPAMCHLORMETHIAZOLEGABOXADOLETIFOXINEHALOTHANEPRIMIDONETALBUTALMEPROBAMATERESEQUINILABP-700ETOMIDATEMETHOXYFLURANEENFLURANELOREDIPLONCLOTIAZEPAMADIPIPLONOCINAPLONBROMAZEPAMZURANOLONEREMIMAZOLAM BESYLATE[3H]AZIETOMIDATEFLURAZEPAM HYDROCHLORIDECIPEPOFOLMETHARBITALETAZOLATEDARIGABATGLUTETHIMIDEPROPOFOLSECOBARBITAL SODIUM
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37563857 | Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. | No related sentences available |