Protein detail
DOCK4
Dedicator of cytokinesis protein 4
Entry name DOCK4 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 16 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Dedicator of cytokinesis protein 4
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization1
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (10)
Molecular Function (7)
Biological Process (3)
Reactome (7)
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence18
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DOCK4 | Q8N1I0 | RAC1 | P63000 | Yes | Yes | No | SIGNOR | SIGNOR:32009906 |
Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DOCK1DOCK3DOCK4DOCK5ELMO1ELMO2USP4ZNF398 | Q13107Q14185Q8IZD9Q8N1I0Q8TD17Q92556Q96JJ3Q9H7D0 | 0:0:0:0:0:0:0:0 | hu.MAP | |||
| DOCK4ELMO1USP4ZNF398 | Q13107Q8N1I0Q8TD17Q92556 | 0:0:0:0 | hu.MAP | |||
| DOCK1DOCK3DOCK4ELMO1ELMO2 | Q14185Q8IZD9Q8N1I0Q92556Q96JJ3 | 0:0:0:0:0 | hu.MAP2 | |||
| DOCK1DOCK3DOCK4DOCK5ELMO1ELMO2 | Q14185Q8IZD9Q8N1I0Q92556Q96JJ3Q9H7D0 | 0:0:0:0:0:0 | hu.MAP2 | |||
| DOCK1DOCK4ELMO1ZNF398 | Q14185Q8N1I0Q8TD17Q92556 | 0:0:0:0 | hu.MAP | |||
| DOCK3DOCK4ELMO1ZNF398 | Q8IZD9Q8N1I0Q8TD17Q92556 | 0:0:0:0 | hu.MAP | |||
| DOCK3DOCK4ELMO1ELMO2 | Q8IZD9Q8N1I0Q92556Q96JJ3 | 0:0:0:0 | hu.MAP2 | |||
| DOCK4ELMO1ELMO2ZNF398 | Q8N1I0Q8TD17Q92556Q96JJ3 | 0:0:0:0 | hu.MAP | |||
| DOCK4DOCK5ELMO1ZNF398 | Q8N1I0Q8TD17Q92556Q9H7D0 | 0:0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40689422 |
Sequence, Structure & Domains12
Sequences
Length
1,966
Mass
225,206
Sequence
MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N1I0-1; Sequence=Displayed; Name=2; Synonyms=DOCK4-Ex49; IsoId=Q8N1I0-2; Sequence=VSP_007703, VSP_007706; Name=3; IsoId=Q8N1I0-3; Sequence=VSP_007703; Name=4; IsoId=Q8N1I0-4; Sequence=VSP_007701, VSP_007705
Alternative Sequence
1..1687; Missing (in isoform 4); 1134; I -> IIPLFGPYPS (in isoform 2 and isoform 3); 1688..1698; NVTSSAPSSAR -> MLMILSLLLFP (in isoform 4); 1760..1797; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1672..1703; Low complexity; 1795..1809; Polar residues; 1838..1863; Low complexity; 1864..1873; Polar residues; 1941..1954; Basic and acidic residues
Motif
1788..1794; SH3-binding
Domain (CC)
The DOCKER domain mediates interaction with small GTPases like RAC1 and is required for their activation.
Domain (FT)
6..67; SH3; 401..574; C2 DOCK-type; 1190..1596; DOCKER
Region
1648..1729; Disordered; 1742..1966; Disordered
Protein Families
DOCK family
Sequence Similarities
Belongs to the DOCK family.
Clinical Relevance3
Interaction Protein
ENSG00000177885
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications15
| PMID | Title | Abstract |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No abstract available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
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