Protein detail

CLC4F

C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13)

Entry name CLC4F	UniProt ID Q8N1N0	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13)

Transmembrane

40..60; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000152672

Entrez Gene Symbol

CLEC4F

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificleukocyte

Function & Pathway5

Cellular Component

GO:0009897 external side of plasma membrane

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M269 Pid ras pathway
M88 Pid cd8 tcr pathway
M34 Pid tcr pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence20

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
receptor	receptor	CellCellInteractions	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	3	39408670 38037300 40689422

Sequence, Structure & Domains6

Sequences

Length

589

Mass

65,519

Sequence

MDGEAVRFCTDNQCVSLHPQEVDSVAMAPAAPKIPRLVQATPAFMAVTLVFSLVTLFVVVQQQTRPVPKPVQAVILGDNITGHLPFEPNNHHHFGREAEMRELIQTFKGHMENSSAWVVEIQMLKCRVDNVNSQLQVLGDHLGNTNADIQMVKGVLKDATTLSLQTQMLRSSLEGTNAEIQRLKEDLEKADALTFQTLNFLKSSLENTSIELHVLSRGLENANSEIQMLNASLETANTQAQLANSSLKNANAEIYVLRGHLDSVNDLRTQNQVLRNSLEGANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNTLNAQIQVLNGHMKNASREIQTLKQGMKNASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQSQLLQMVLQGWKFNGGSLYYFSSVKKSWHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVYYWIGLTDRGTEGSWRWTDGTPFNAAQNKAPGSKGSCPLRKYIIVNSGMGACSFIDTPPCPWILSN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N1N0-1; Sequence=Displayed; Name=2; IsoId=Q8N1N0-2; Sequence=VSP_056330

Alternative Sequence

554..589; PGSKGSCPLRKYIIVNSGMGACSFIDTPPCPWILSN -> SHSTRKGCCLHLTV (in isoform 2)

Domain & Motif Annotations

Domain (FT)

476..589; C-type lectin

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available