Protein detail
ARG28
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Entry name ARG28 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
p190RhoGEFRGNEFRIP2
Gene Description
Rho guanine nucleotide exchange factor 28
Chromosome
5
Position
73626158-73941993
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
Reactome (8)
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-2682334 eph ephrin signaling
- R-hsa-9675108 nervous system development
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways (3)
- M269 Pid ras pathway
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence12
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GNAQ | P50148 | ARG28 | Q8N1W1 | Yes | Yes | SIGNOR | SIGNOR:25922072 | |
| FAK1 | Q05397 | ARG28 | Q8N1W1 | Yes | Yes | KEGG-MEDICUSWangSIGNOR | SIGNOR:21643014 | |
| ARG28 | Q8N1W1 | RHOA | P61586 | Yes | Yes | KEGG-MEDICUSWangHINTSIGNOR | HINT:29196061SIGNOR:32203420HINT:32203420 | |
| GNA13 | Q14344 | ARG28 | Q8N1W1 | Yes | Yes | SIGNOR | SIGNOR:25922072 |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
1,705
Mass
191,891
Sequence
MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVPGHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLTPFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASLHYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAETEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPTETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQEEEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLCHENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPSNVSHKLWTAAGSGHQILPFHESSKDSCKNDLDTSHTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDGETGDGAKENIVYL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8N1W1-1; Sequence=Displayed; Name=2; IsoId=Q8N1W1-2; Sequence=VSP_032140, VSP_032141; Name=3; IsoId=Q8N1W1-3; Sequence=VSP_032142, VSP_032143; Name=4; IsoId=Q8N1W1-4; Sequence=VSP_032144; Name=5; IsoId=Q8N1W1-5; Sequence=VSP_044737, VSP_044738; Name=6; IsoId=Q8N1W1-6; Sequence=VSP_032143
Alternative Sequence
1..28; MELSCSEAPLYGQMMIYAKFDKNVYLPE -> MDSDSDSPFNYSWPSFPKMKIRRRTSKQ (in isoform 5); 29..341; Missing (in isoform 5); 583..602; EQRAYSLSEPPRENRIQEEE -> GKHHLTFGFENTLFQNRFFS (in isoform 2); 603..1705; Missing (in isoform 2); 1282..1325; Missing (in isoform 3); 1649; N -> NGSSMTKCSCTLTSPPGLWTGTTSTLK (in isoform 3 and isoform 6); 1650..1705; DLDTSHTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDGETGDGAKENIVYL -> GN (in isoform 4)
3D Structural Models
Helix
1052..1060; 1077..1080; 1138..1140; 1173..1184
Beta Strand
1066..1068; 1074..1076; 1088..1096; 1102..1109; 1114..1120; 1123..1126; 1134..1136; 1141..1145; 1152..1157; 1164..1169
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
501..510; Polar residues; 640..649; Basic and acidic residues; 710..721; Polar residues; 759..775; Polar residues; 777..791; Basic and acidic residues; 1191..1207; Basic and acidic residues; 1641..1655; Basic and acidic residues; 1656..1669; Polar residues; 1688..1699; Basic and acidic residues
Coiled Coil
1488..1525
Zinc Finger
652..699; Phorbol-ester/DAG-type
Domain (FT)
849..1044; DH; 1086..1188; PH
Region
287..316; Disordered; 473..524; Disordered; 630..649; Disordered; 710..800; Disordered; 1187..1207; Disordered; 1295..1304; Interaction with PTK2/FAK1; required for regulation of axonal branching and synapse formation; 1312..1339; Disordered; 1372..1383; Mediates cytoplasmic retention and interaction with YWHAH; 1425..1705; Interaction with microtubules; 1496..1527; RNA-binding; 1566..1579; Mediates cytoplasmic retention and interaction with MAPK8IP1; 1638..1705; Disordered
Clinical Relevance
Antibody
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |