Protein detail
PROM2
Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)
Entry name PROM2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 5 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Prominin-2 (PROM-2) (Prominin-like protein 2) (hPROML2)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters
Transmembrane
107..127; Helical; 154..174; Helical; 427..447; Helical; 473..493; Helical; 780..800; Helical
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Gene Description
Prominin 2
Chromosome
2
Position
95274449-95291308
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization6
Tissue SpecificlungCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificependymal cellBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function
Transporters
Cellular Component (14)
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005929 cilium
- GO:0009986 cell surface
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0031410 cytoplasmic vesicle
- GO:0031528 microvillus membrane
- GO:0042995 cell projection
- GO:0044393 microspike
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Molecular Function (2)
Biological Process (3)
Canonical Pathways
M269 Pid ras pathway
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence22
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryWestern blottingMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]R Sequencing | 10 | 33353163329386813289403931331117308935113014251134779491256648543786238138375617 |
Sequence, Structure & Domains7
Sequences
Length
834
Mass
91,883
Sequence
MKHTLALLAPLLGLGLGLALSQLAAGATDCKFLGPAEHLTFTPAARARWLAPRVRAPGLLDSLYGTVRRFLSVVQLNPFPSELVKALLNELASVKVNEVVRYEAGYVVCAVIAGLYLLLVPTAGLCFCCCRCHRRCGGRVKTEHKALACERAALMVFLLLTTLLLLIGVVCAFVTNQRTHEQMGPSIEAMPETLLSLWGLVSDVPQELQAVAQQFSLPQEQVSEELDGVGVSIGSAIHTQLRSSVYPLLAAVGSLGQVLQVSVHHLQTLNATVVELQAGQQDLEPAIREHRDRLLELLQEARCQGDCAGALSWARTLELGADFSQVPSVDHVLHQLKGVPEANFSSMVQEENSTFNALPALAAMQTSSVVQELKKAVAQQPEGVRTLAEGFPGLEAASRWAQALQEVEESSRPYLQEVQRYETYRWIVGCVLCSVVLFVVLCNLLGLNLGIWGLSARDDPSHPEAKGEAGARFLMAGVGLSFLFAAPLILLVFATFLVGGNVQTLVCQSWENGELFEFADTPGNLPPSMNLSQLLGLRKNISIHQAYQQCKEGAALWTVLQLNDSYDLEEHLDINQYTNKLRQELQSLKVDTQSLDLLSSAARRDLEALQSSGLQRIHYPDFLVQIQRPVVKTSMEQLAQELQGLAQAQDNSVLGQRLQEEAQGLRNLHQEKVVPQQSLVAKLNLSVRALESSAPNLQLETSDVLANVTYLKGELPAWAARILRNVSECFLAREMGYFSQYVAWVREEVTQRIATCQPLSGALDNSRVILCDMMADPWNAFWFCLAWCTFFLIPSIIFAVKTSKYFRPIRKRLSSTSSEETQLFHIPRVTSLKL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N271-1; Sequence=Displayed; Name=2; IsoId=Q8N271-2; Sequence=VSP_033149; Name=3; IsoId=Q8N271-3; Sequence=VSP_033148
Alternative Sequence
1..474; Missing (in isoform 3); 576..624; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
Prominin family
Sequence Similarities
Belongs to the prominin family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 36028467 | Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment. | No abstract available |