Protein detail

ANR35

Ankyrin repeat domain-containing protein 35

Entry name ANR35	UniProt ID Q8N283	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Ankyrin repeat domain-containing protein 35

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000198483

Entrez Gene Symbol

ANKRD35

Gene Synonym

FLJ25124

Gene Description

Ankyrin repeat domain 35

Chromosome

Position

145866560-145885866

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue Specificthyroid glandCell SpecificAdipocytesBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor

Function & Pathway4

Protein Function

Predicted intracellular proteins

Biological Process (3)

Canonical Pathways (2)

M256 Pid tap63 pathway
M19 Pid p73pathway

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains9

Sequences

Length

1,001

Mass

109,937

Sequence

MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGAQGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPQAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N283-1; Sequence=Displayed; Name=2; IsoId=Q8N283-2; Sequence=VSP_056916, VSP_056917

Alternative Sequence

109..137; HGANEDAVDAENRSPLHWAASSGCASSVL -> PPLAVPQVCSCCVTTKPSWTCWIMMDVHP (in isoform 2); 138..1001; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

281..295; Acidic residues; 402..422; Basic and acidic residues; 423..434; Low complexity; 440..450; Polar residues; 579..588; Basic and acidic residues; 890..902; Basic and acidic residues

Repeat

53..82; ANK 1; 86..115; ANK 2; 119..148; ANK 3; 152..181; ANK 4; 185..214; ANK 5; 218..247; ANK 6

Coiled Coil

295..344; 610..696; 733..810; 851..968

Region

256..296; Disordered; 352..482; Disordered; 559..601; Disordered; 879..902; Disordered

Clinical Relevance1

Antibody

HPA035453

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available