Protein detail
ANR35
Ankyrin repeat domain-containing protein 35
Protein symbol ANR35 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Essential proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ankyrin repeat domain-containing protein 35
Protein Class
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ25124
Gene Description
Ankyrin repeat domain 35
Chromosome
1
Position
145866560-145885866
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificthyroid glandCell SpecificAdipocytesBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
Predicted intracellular proteins
Biological Process
Canonical Pathways
- M256 Pid tap63 pathway
- M19 Pid p73pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
2 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
1,001
Mass
109,937
Sequence
MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKDLLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGAQGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPQAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSMEEE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N283-1; Sequence=Displayed; Name=2; IsoId=Q8N283-2; Sequence=VSP_056916, VSP_056917
Alternative Sequence
109..137; HGANEDAVDAENRSPLHWAASSGCASSVL -> PPLAVPQVCSCCVTTKPSWTCWIMMDVHP (in isoform 2); 138..1001; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
281..295; Acidic residues; 402..422; Basic and acidic residues; 423..434; Low complexity; 440..450; Polar residues; 579..588; Basic and acidic residues; 890..902; Basic and acidic residues
Repeat
53..82; ANK 1; 86..115; ANK 2; 119..148; ANK 3; 152..181; ANK 4; 185..214; ANK 5; 218..247; ANK 6
Coiled Coil
295..344; 610..696; 733..810; 851..968
Region
256..296; Disordered; 352..482; Disordered; 559..601; Disordered; 879..902; Disordered
Clinical Relevance
Antibody