Protein detail
NLGN1
Neuroligin-1
Entry name NLGN1 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuroligin-1
Protein Class (6)
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
718..738; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1070
Gene Description
Neuroligin 1
Chromosome
3
Position
173396284-174294372
Supporting publications (n)
11
EVMP confidence score
0.60
Fluorescence & Localization
Function & Pathway
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component (21)
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0031594 neuromuscular junction
- GO:0032433 filopodium tip
- GO:0043083 synaptic cleft
- GO:0043197 dendritic spine
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Molecular Function (7)
Biological Process (3)
Reactome (3)
Canonical Pathways
M12 Pid rhoa pathway
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence59
Ligand-Receptor Signaling (50)
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | Yes | ||
| receptor | receptor | CellChatDB | Yes | Yes | Yes | ||
| receptor | receptor | Baccin2019 | Yes | Yes | Yes | ||
| receptor | receptor | OmniPath | Yes | Yes | Yes | ||
| extracellular | extracellular | OmniPath | Yes | Yes | |||
| intracellular | intracellular | LOCATE | Yes | Yes | |||
| intracellular | intracellular | GO_Intercell | Yes | Yes | |||
| intracellular | intracellular | OmniPath | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | Yes | Yes |
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Regulatory Interaction Network (7)
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NLGN1 | Q8N2Q7 | DLG4 | P78352 | Yes | Yes | DOMINOWangSIGNORHPRDCui2007HINTBioGRIDCA1SPIKE_LCLit-BM-17 | DOMINO:11937501BioGRID:30864948SIGNOR:18923512HINT:30864948SPIKE_LC:11937501CA1:9278515Lit-BM-17:11937501Lit-BM-17:9278515HINT:9278515HPRD:9278515 | |
| NLGN1 | Q8N2Q7 | NRX3B | Q9HDB5 | Yes | Yes | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 | |
| NLGN1 | Q8N2Q7 | NRX3A | Q9Y4C0 | Yes | Yes | CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Cellinker:8576240CellTalkDB:8576240 | |
| NLGN1 | Q8N2Q7 | NRX1A | Q9ULB1 | Yes | Yes | iTALKICELLNETSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:8576240Cellinker:14522992HPRD:14522992ICELLNET:22750515BioGRID:8576240LRdb:145BioGRID:14522992SIGNOR:18923512BioGRID:12796785connectomeDB2020:14522992HINT:14522992Baccin2019:8576240LRdb:8576240Baccin2019:14522992connectomeDB2020:8576240HPRD:8576240HINT:12796785HINT:8576240CellTalkDB:8576240 | |
| NLGN1 | Q8N2Q7 | NRX1B | P58400 | Yes | Yes | iTALKICELLNETSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:8576240Cellinker:14522992HPRD:14522992ICELLNET:22750515BioGRID:8576240LRdb:145BioGRID:14522992SIGNOR:18923512BioGRID:12796785connectomeDB2020:14522992HINT:14522992Baccin2019:8576240LRdb:8576240Baccin2019:14522992connectomeDB2020:8576240HPRD:8576240HINT:12796785HINT:8576240CellTalkDB:8576240 | |
| NLGN1 | Q8N2Q7 | NRX2A | Q9P2S2 | Yes | Yes | CellTalkDBFantom5_LRdbiTALKCellPhoneDBtalklrSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015 | connectomeDB2020:7736595SIGNOR:18923512CellTalkDB:7736595LRdb:7736595Ramilowski2015:7736595talklr:7736595 | |
| NLGN1 | Q8N2Q7 | NRX2B | P58401 | Yes | Yes | CellTalkDBFantom5_LRdbiTALKCellPhoneDBtalklrSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015 | connectomeDB2020:7736595SIGNOR:18923512CellTalkDB:7736595LRdb:7736595Ramilowski2015:7736595talklr:7736595 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
863
Mass
96,368
Sequence
MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N2Q7-3; Sequence=Displayed; Name=2; IsoId=Q8N2Q7-2; Sequence=VSP_060231
Alternative Sequence
165..204; Missing (in isoform 2)
3D Structural Models
Turn
128..130; 429..432; 437..439; 545..548; 609..612; 620..622; 653..655
Helix
91..93; 133..137; 139..144; 229..231; 235..241; 253..257; 269..284; 285..288; 302..311; 314..316; 349..359; 367..374; 379..383; 409..414; 433..436; 448..462; 469..479; 483..485; 489..504; 506..518; 549..553; 555..558; 570..589; 640..647; 649..652
Beta Strand
54..57; 60..63; 65..67; 72..74; 77..84; 105..109; 122..125; 147..149; 155..160; 213..218; 222..226; 243..248; 261..264; 290..300; 327..336; 339..341; 395..397; 402..405; 422..428; 442..444; 466..468; 523..528; 562..564; 594..596; 624..631; 633..637
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
194..206; Acidic residues; 681..690; Polar residues; 851..863; Basic residues
Region
183..212; Disordered; 670..708; Disordered; 842..863; Disordered
Protein Families
Type-B carboxylesterase/lipase family
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
Clinical Relevance
Disease Involvement (3)
AutismAutism spectrum disorderDisease variant
Related Diseases (2)
Drugs
Supporting Publications11
| PMID | Title | Related sentences |
|---|---|---|
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No related sentences available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No related sentences available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No related sentences available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No related sentences available |
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No related sentences available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No related sentences available |
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