Protein detail

NLGN1

Neuroligin-1

Entry name NLGN1	UniProt ID Q8N2Q7	EVMP confidence score 0.72
Supporting publications (n) 11	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Neuroligin-1

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

718..738; Helical

Transmembrane Count

Ensembl

ENSG00000169760

Entrez Gene Symbol

NLGN1

Gene Synonym

KIAA1070

Gene Description

Neuroligin 1

Chromosome

Position

173396284-174294372

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization1

Function & Pathway8

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (21)

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Molecular Function (7)

Biological Process (3)

KEGG (2)

Reactome (3)

Canonical Pathways

M12 Pid rhoa pathway

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence59

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	No
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NLGN1	Q8N2Q7	DLG4	P78352	Yes	Yes	No	DOMINOWangSIGNORHPRDCui2007HINTBioGRIDCA1SPIKE_LCLit-BM-17	DOMINO:11937501 BioGRID:30864948 SIGNOR:18923512 HINT:30864948 SPIKE_LC:11937501 CA1:9278515 Lit-BM-17:11937501 Lit-BM-17:9278515 HINT:9278515 HPRD:9278515
NLGN1	Q8N2Q7	NRX3B	Q9HDB5	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NLGN1	Q8N2Q7	NRX3A	Q9Y4C0	Yes	Yes	No	CellTalkDBFantom5_LRdbHPMR_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	LRdb:8576240 connectomeDB2020:8576240 SIGNOR:18923512 Cellinker:8576240 CellTalkDB:8576240
NLGN1	Q8N2Q7	NRX1A	Q9ULB1	Yes	Yes	No	iTALKICELLNETSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:8576240 Cellinker:14522992 HPRD:14522992 ICELLNET:22750515 BioGRID:8576240LRdb:145BioGRID:14522992 SIGNOR:18923512 BioGRID:12796785 connectomeDB2020:14522992 HINT:14522992 Baccin2019:8576240 LRdb:8576240 Baccin2019:14522992 connectomeDB2020:8576240 HPRD:8576240 HINT:12796785 HINT:8576240 CellTalkDB:8576240
NLGN1	Q8N2Q7	NRX1B	P58400	Yes	Yes	No	iTALKICELLNETSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:8576240 Cellinker:14522992 HPRD:14522992 ICELLNET:22750515 BioGRID:8576240LRdb:145BioGRID:14522992 SIGNOR:18923512 BioGRID:12796785 connectomeDB2020:14522992 HINT:14522992 Baccin2019:8576240 LRdb:8576240 Baccin2019:14522992 connectomeDB2020:8576240 HPRD:8576240 HINT:12796785 HINT:8576240 CellTalkDB:8576240
NLGN1	Q8N2Q7	NRX2A	Q9P2S2	Yes	Yes	No	CellTalkDBFantom5_LRdbiTALKCellPhoneDBtalklrSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015	connectomeDB2020:7736595 SIGNOR:18923512 CellTalkDB:7736595 LRdb:7736595 Ramilowski2015:7736595 talklr:7736595
NLGN1	Q8N2Q7	NRX2B	P58401	Yes	Yes	No	CellTalkDBFantom5_LRdbiTALKCellPhoneDBtalklrSIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015	connectomeDB2020:7736595 SIGNOR:18923512 CellTalkDB:7736595 LRdb:7736595 Ramilowski2015:7736595 talklr:7736595

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NLGN1	Q8N2Q7	2	PDB	PDB:5ojk

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	1	38716512

Sequence, Structure & Domains13

Sequences

Length

863

Mass

96,368

Sequence

MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N2Q7-3; Sequence=Displayed; Name=2; IsoId=Q8N2Q7-2; Sequence=VSP_060231

Alternative Sequence

165..204; Missing (in isoform 2)

3D Structural Models

Turn

128..130; 429..432; 437..439; 545..548; 609..612; 620..622; 653..655

Helix

91..93; 133..137; 139..144; 229..231; 235..241; 253..257; 269..284; 285..288; 302..311; 314..316; 349..359; 367..374; 379..383; 409..414; 433..436; 448..462; 469..479; 483..485; 489..504; 506..518; 549..553; 555..558; 570..589; 640..647; 649..652

Beta Strand

54..57; 60..63; 65..67; 72..74; 77..84; 105..109; 122..125; 147..149; 155..160; 213..218; 222..226; 243..248; 261..264; 290..300; 327..336; 339..341; 395..397; 402..405; 422..428; 442..444; 466..468; 523..528; 562..564; 594..596; 624..631; 633..637

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

194..206; Acidic residues; 681..690; Polar residues; 851..863; Basic residues

Region

183..212; Disordered; 670..708; Disordered; 842..863; Disordered

Protein Families

Type-B carboxylesterase/lipase family

Sequence Similarities

Belongs to the type-B carboxylesterase/lipase family.

Clinical Relevance3

Disease Involvement (3)

AutismAutism spectrum disorderDisease variant

Drugs

FLUOROURACIL

Antibody (3)

HPA006572 HPA006680 CAB033261

Supporting Publications11

PMID	Title	Abstract
30608700	Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available
37862381	Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
40311616	Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.	No abstract available

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