Protein detail
MUC20
Mucin-20 (MUC-20)
Entry name MUC20 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Mucin-20 (MUC-20)
Protein Function (2)
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificColonocytes
Function & Pathway6
Protein Function (2)
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function
Biological Process (3)
Reactome (15)
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-5621480 dectin 2 family
- R-hsa-5083632 defective c1galt1c1 causes tnps
- R-hsa-5083625 defective galnt3 causes hftc
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-168249 innate immune system
- R-hsa-8851805 met activates ras signaling
- R-hsa-5173105 o linked glycosylation
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Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| mucin | ecm | OmniPath | Yes | No | Yes | No | No |
| mucin | ecm | Matrisome | Yes | No | Yes | No | No |
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Sequence, Structure & Domains8
Sequences
Length
709
Mass
71,982
Sequence
MGCLWGLALPLFFFCWEVGVSGSSAGPSTRRADTAMTTDDTEVPAMTLAPGHAALETQTLSAETSSRASTPAGPIPEAETRGAKRISPARETRSFTKTSPNFMVLIATSVETSAASGSPEGAGMTTVQTITGSDPREAIFDTLCTDDSSEEAKTLTMDILTLAHTSTEAKGLSSESSASSDSPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSRASESSASSDGLHPVITPSRASESSASSDGPHPVITPSRASESSASSDGPHPVITPSWSPGSDVTLLAEALVTVTNIEVINCSITEIETTTSSIPGASDTDLIPTEGVKASSTSDPPALPDSTEAKPHITEVTASAETLSTAGTTESAAPDATVGTPLPTNSATEREVTAPGATTLSGALVTVSRNPLEETSALSVETPSYVKVSGAAPVSIEAGSAVGKTTSFAGSSASSYSPSEAALKNFTPSETPTMDIATKGPFPTSRDPLPSVPPTTTNSSRGTNSTLAKITTSAKTTMKPPTATPTTARTRPTTDVSAGENGGFLLLRLSVASPEDLTDPRVAERLMQQLHRELHAHAPHFQVSLLRVRRG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=hMUC20-L; IsoId=Q8N307-1; Sequence=Displayed; Name=2; Synonyms=hMUC20-S; IsoId=Q8N307-3; Sequence=VSP_030980
Alternative Sequence
1..35; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
57..69; Polar residues; 78..92; Basic and acidic residues; 173..182; Low complexity; 190..199; Low complexity; 209..218; Low complexity; 228..237; Low complexity; 247..256; Low complexity; 266..275; Low complexity; 285..294; Low complexity; 304..313; Low complexity; 323..332; Low complexity; 342..351; Low complexity; 361..370; Low complexity; 380..389; Low complexity; 474..489; Polar residues; 613..652; Low complexity
Repeat
173..192; 1; 193..211; 2; 212..230; 3; 231..249; 4; 250..268; 5; 269..287; 6; 288..306; 7; 307..325; 8; 326..344; 9; 345..363; 10; 364..382; 11; 383..400; 12; approximate
Region
57..92; Disordered; 170..403; Disordered; 173..400; 12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A; 434..515; Disordered; 450..656; Involved in oligomerization; 583..657; Disordered; 657..709; Interaction with MET
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |