EV MemProt Atlas

Basic Information5

Protein Names

Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1-L) (EC 1.1.1.8)

Protein Function (6)

ENZYME proteins:Oxidoreductases
Predicted intracellular proteins
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases

Ensembl

ENSG00000152642

Entrez Gene Symbol

GPD1L

EVMP confidence score

0.38

Function & Pathway7

Protein Function (6)

ENZYME proteins:Oxidoreductases
Predicted intracellular proteins
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases

Cellular Component (3)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (4)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence10

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ATAD3B GPD1L POTEE RRM1 RRM2 RRM2B UBC	P0CG48 P23921 P31350 Q5T9A4 Q6S8J3 Q7LG56 Q8N335	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8167
GPD1 GPD1L	P21695 Q8N335	0:0	hu.MAP2
COQ5 GPD1L PCBD1	P61457 Q5HYK3 Q8N335	0:0:0	hu.MAP
COQ5 GPD1L MDN1 PCBD1	P61457 Q5HYK3 Q8N335 Q9NU22	0:0:0:0	hu.MAP
GPD1L	Q8N335	2	PDB	PDB:2pla

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Fetch_Error	Mass spectrometryFACS\|Western blottingWestern blottingMass spectrometry\|Western blotting\|FACSFACSMass spectrometry [LTQ-FT Ultra]\|Western blottingWestern blotting\|FACSMass spectrometry [QTOF]Mass spectrometry\|Western blottingWestern blotting\|Flow cytometric alysis\|Mass spectrometryFlow cytometryImmunofluorescenceImmuno-EMWestern blotting\|immuno-EM	424	33367429 33363470 33358817 33345458 33334882 33330567 33328332 33316880 33315384 33307173 33275138 33250449 33182773 33155413 33101656 33023058 32951259 32944195 32930202 32893620 32874118 32822875 32820307 32801874 32795414 32793278 32767662 32747437 32730952 32713614 32600030 32589377 32544615 32495928 32487603 32483153 32424440 32416091 32409751 32350244 32338917 32328746 32319557 32232928 32207293 32151262 32127037 32126572 32101370 32081419 32054015 31999742 31934115 31894881 31885909 31878991 31858380 31823250 31800531 31792471 31786017 31766102 31749189 31712601 31675489 31648466 31641193 31638563 31611757 31594209 31473497 31410448 31407387 31399645 31399634 31220525 31196738 31136209 31100946 31090350 31078263 31048929 31044144 31035355 31022607 31015841 30990781 30982221 30930201 30911413 30904547 30898155 30891102 30830528 30825338 30817089 30796693 30777349 30733650 30680751 30678441 30613011 30262875 30251702 30248150 30198786 30191215 30187874 30126376 30098419 30043563 30032860 30021922 29986939 29945314 29933408 29911857 29908844 29891991 29884298 29740045 29739042 29723143 29720199 29707602 29592957 29575602 29521294 29518183 29468680 29336475 10545503 14633944 15284116 16027013 32127037 32151262 32951259 33386754 33413616 33456364 33497388 33558596 33565399 33572290 33649776 33669497 33717398 33724661 33725248 33766230 33773551 33808296 33834667 33925027 33962471 33971889 33995680 34012515 34028833 34065240 34071980 34122615 34141904 34164201 34173219 34181396 34181894 34212056 34229300 34258353 34282141 34284286 34284947 34366842 34384449 34407878 34429639 34434533 34462474 34473505 34505435 34534861 34542679 34551201 34562426 34564576 34567283 34576100 34680341 34681566 34684727 34686196 34698510 34742829 34745768 34800917 34847362 34900726 34926194 34926195 34965880 34982509 35006577 35053007 35143105 35175564 35182062 35228162 35259607 35260179 35274316 35301156 35330909 35345318 35409043 35647028 35657460 35689956 35700522 35732548 35794239 35838333 35896586 35922742 35930994 35939349 35950642 35957917 35963322 36060136 36063301 36077715 36093484 36108271 36119932 36130685 36175423 36190183 36225174 36240643 36312392 36324609 36353645 36359760 36466784 36527848 36585155 16407131 17407154 17484880 17894858 18802920 19810033 20124223 20138817 20880880 21172122 21235781 21651777 22133690 22285593 22895844 23289620 23462321 23516492 23861904 23946286 24009888 24058665 24069378 24122827 24144866 24146068 24269592 24371518 24393345 24424840 24956264 24976626 24982349 25167841 25214786 25319668 25338648 25368198 25473095 25711438 25732677 25735706 25833959 25849885 25997717 26109643 26139298 26447809 26452221 26709901 26780239 26973197 27048572 27317346 27329675 27333275 27336721 27343445 27345057 27356893 27379194 27443953 27460850 27464736 27536982 27542209 27564521 27569704 27592404 27716356 27734678 27856179 28025988 28074869 28105054 28114422 28160564 28251957 28345878 28346015 28350875 28360912 28414289 28469780 28476099 28476471 28534915 28542562 28629620 28701751 28740388 28823103 28847700 28850588 28878075 28881726 29116068 29221804 35006577 35053007 35259607 35260179 35647028 35732548 35838333 36203458 36203609 36240643 36312392 36324609 36359760 36576666 36585155 36638529 36640525 36688929 36704890 36715074 36722691 36759883 36777859 36815255 36826611 36945515 37007105 37009008 37014542 37042872 37084607 37087587 37106519 37109070 37124929 37125533 37198427 37307147 37345178 37357556 37386835 37445655 37479071 37536457 37948136 37968711 38069981 38072191 38072803 38095642 38151158 38159254 38199177 38282606 38341004 38384937 38430799 38439112 38440154 38502973 38624007 38630028 38684330 38699039 38718108 38783745 38842768 38852279 38874800 38922971 39002259 39034117 39147191 39147261 39174921 39222871 39230197 39299675

Sequence, Structure & Domains9

Sequences

Length

351

Mass

38,419

Sequence

MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT

3D Structural Models

Turn

63..65; 257..259

Helix

15..28; 52..59; 81..85; 97..99; 100..107; 134..142; 155..159; 173..183; 196..218; 223..244; 251..254; 260..269; 271..282; 286..294; 301..315; 318..320; 322..332; 339..345

Beta Strand

8..11; 38..41; 75..79; 89..93; 116..119; 124..127; 130..133; 144..152; 164..169; 188..194; 245..247

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

NAD-dependent glycerol-3-phosphate dehydrogenase family

Sequence Similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Entry name GPD1L	UniProt ID Q8N335	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count	Protein classification