Protein detail
TMTC2
Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)
Entry name TMTC2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 11 | Protein classification EnzymesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)
Protein Class (2)
EnzymesPredicted membrane proteins
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Transmembrane
1..21; Helical; 85..105; Helical; 108..128; Helical; 133..153; Helical; 163..184; Helical; 185..204; Helical; 221..241; Helical; 313..333; Helical; 400..420; Helical; 423..443; Helical; 450..470; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp762A217
Gene Description
Transmembrane O-mannosyltransferase targeting cadherins 2
Chromosome
12
Position
82686880-83134870
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecificretinaCell SpecificAlveolar cells type 1Blood Cell SpecificgdT-cellBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (2)
- M82 Pid ret pathway
- M142 Pid ajdiss 2pathway
Mediation Categories
Metabolism mediation
Relations & Evidence12
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 2 of 2Previous
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains6
Sequences
Length
836
Mass
94,130
Sequence
MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT
Domain & Motif Annotations
Repeat
493..526; TPR 1; 527..560; TPR 2; 561..594; TPR 3; 606..639; TPR 4; 643..676; TPR 5; 677..710; TPR 6; 711..744; TPR 7; 745..778; TPR 8; 779..812; TPR 9
Protein Families
TMTC family
Sequence Similarities
Belongs to the TMTC family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |