Protein detail
PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
Protein symbol PLCD3 | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)
Protein Class
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Description
Phospholipase C delta 3
Chromosome
17
Position
45108959-45133354
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEnterocytes
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Flow Cytometry | 1 | 33553692 |
Sequence, Structure & Domains
Sequences
Length
789
Mass
89,258
Sequence
MLCGRWRRCRRPPEEPPVAAQVAAQVAAPVALPSPPTPSDGGTKRPGLRALKKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQRS
3D Structural Models
Domain & Motif Annotations
Compositional Bias
488..497; Basic and acidic residues; 498..513; Acidic residues
Domain (CC)
The C2 domain is a Ca(2+)-dependent membrane-targeting module.; DOMAIN: The PH domain mediates interaction with the surface membrane by binding to PIP2..
Domain (FT)
63..172; PH; 182..217; EF-hand 1; 218..253; EF-hand 2; 250..285; EF-hand 3; 337..482; PI-PLC X-box; 528..644; PI-PLC Y-box; 644..769; C2
Region
73..101; Substrate binding; 461..519; Disordered