Protein detail
CADM2
Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)
Entry name CADM2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2)
Protein Class
Predicted membrane proteins
Transmembrane
368..388; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
IGSF4DNecl-3NECL3SynCAM2
Gene Description
Cell adhesion molecule 2
Chromosome
3
Position
84958989-86074429
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue SpecificgallbladderCell SpecificCholangiocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway6
Cellular Component (4)
Biological Process (3)
Reactome (3)
Canonical Pathways
M257 Pid ephrinb rev pathway
Mediation Categories (2)
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| nectin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| ig_like | adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryELISA | 1 | 33592500 |
Sequence, Structure & Domains8
Sequences
Length
435
Mass
47,554
Sequence
MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8N3J6-1; Sequence=Displayed; Name=2; IsoId=Q8N3J6-2; Sequence=VSP_026334, VSP_026335; Name=3; IsoId=Q8N3J6-3; Sequence=VSP_026333; Name=5; Synonyms=7; IsoId=Q8N3J6-4; Sequence=VSP_055355, VSP_055356; Name=6; Synonyms=8; IsoId=Q8N3J6-5; Sequence=VSP_055355
Alternative Sequence
1..108; Missing (in isoform 5 and isoform 6); 1..20; MIWKRSAVLRFYSVCGLLLQ -> MFVLFLCNLSLVPAAASKNKVK (in isoform 3); 20; Q -> QAAASKNKVK (in isoform 2); 315..354; Missing (in isoform 5); 316..355; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
27..119; Ig-like V-type; 127..219; Ig-like C2-type 1; 227..312; Ig-like C2-type 2
Protein Families
Nectin family
Sequence Similarities
Belongs to the nectin family.
Clinical Relevance2
Drugs
Antibody